Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor vemurafenib in human and mouse plasma

Keyphrases

• Mass Spectrometry 100%
• Human Plasma 100%
• Spectrometric Assay 100%
• Liquid Chromatography-tandem Mass 100%
• Mouse Plasma 100%
• Vemurafenib 100%
• BRAF Inhibitor (BRAFi) 100%
• Methanol 50%
• Bioanalytical Assay 50%
• Pharmacokinetics 50%
• Between-day 50%
• Protein Precipitation 50%
• Triple Quadrupole Mass Spectrometer 50%
• Formic Acid 50%
• Monitoring Mode 50%
• Eluate 50%
• Chromatographic System 50%
• Electrospray Interface 50%
• Selected Reaction Monitoring 50%
• Acetonitrile-water Mixtures 50%
• Isocratic Elution 50%
• Sorafenib 50%
• Human Plasma Samples 50%
• Tri-functional 50%
• Drug Levels 50%
• Octadecyl Silica 50%
• Silica Column 50%
• Quantitative Assay 50%

Chemistry

• Liquid Chromatography 100%
• Vemurafenib 100%
• Methanol 50%
• Electrosprays 50%
• Pharmacokinetics 50%
• Quadrupole 50%
• Protein Precipitation 50%
• Silicon Dioxide 50%
• Acetonitrile 50%
• Formic Acid 50%
• Sorafenib 50%