Lipid Therapy for Intoxications

Joris Henricus Robben; Marieke Annet Dijkman

doi:10.1016/j.cvsm.2016.10.018

Lipid Therapy for Intoxications

Joris Henricus Robben, Marieke Annet Dijkman

Utrecht University

Research output: Contribution to journal › Article › Academic

1 Downloads (Pure)

Abstract

This review discusses the use of intravenous lipid emulsion (ILE) in the treatment of intoxications with lipophilic agents in veterinary medicine. Despite growing scientific evidence that ILE has merit in the treatment of certain poisonings, there is still uncertainty on the optimal composition of the lipid emulsion, the dosing, the mechanism of action, and the efficacy. Therefore, a critical view of the clinician on the applicability of this modality in intoxications is still warranted. The use of ILE therapy is advocated as an antidote in cases of intoxications with some lipophilic substances.

Original language	English
Pages (from-to)	435–450
Journal	Veterinary Clinics of North America - Small Animal Practice
Volume	47
Issue number	2
DOIs	https://doi.org/10.1016/j.cvsm.2016.10.018
Publication status	Published - Mar 2017

Keywords

Poisoning
Toxin
Lipid
Fat
Emulsion
Intralipid
ILE
Lipid resuscitation therapy

Access to Document

10.1016/j.cvsm.2016.10.018

LipidFinal published version, 448 KBLicence: Taverne

Cite this

@article{534a8ddb11f9439d87dadb43d8d41108,

title = "Lipid Therapy for Intoxications",

abstract = "This review discusses the use of intravenous lipid emulsion (ILE) in the treatment of intoxications with lipophilic agents in veterinary medicine. Despite growing scientific evidence that ILE has merit in the treatment of certain poisonings, there is still uncertainty on the optimal composition of the lipid emulsion, the dosing, the mechanism of action, and the efficacy. Therefore, a critical view of the clinician on the applicability of this modality in intoxications is still warranted. The use of ILE therapy is advocated as an antidote in cases of intoxications with some lipophilic substances.",

keywords = "Poisoning, Toxin, Lipid, Fat, Emulsion, Intralipid, ILE, Lipid resuscitation therapy",

author = "Robben, {Joris Henricus} and Dijkman, {Marieke Annet}",

year = "2017",

month = mar,

doi = "10.1016/j.cvsm.2016.10.018",

language = "English",

volume = "47",

pages = "435–450",

journal = "Veterinary Clinics of North America - Small Animal Practice",

issn = "0195-5616",

publisher = "W.B. Saunders Ltd",

number = "2",

}

TY - JOUR

T1 - Lipid Therapy for Intoxications

AU - Robben, Joris Henricus

AU - Dijkman, Marieke Annet

PY - 2017/3

Y1 - 2017/3

N2 - This review discusses the use of intravenous lipid emulsion (ILE) in the treatment of intoxications with lipophilic agents in veterinary medicine. Despite growing scientific evidence that ILE has merit in the treatment of certain poisonings, there is still uncertainty on the optimal composition of the lipid emulsion, the dosing, the mechanism of action, and the efficacy. Therefore, a critical view of the clinician on the applicability of this modality in intoxications is still warranted. The use of ILE therapy is advocated as an antidote in cases of intoxications with some lipophilic substances.

AB - This review discusses the use of intravenous lipid emulsion (ILE) in the treatment of intoxications with lipophilic agents in veterinary medicine. Despite growing scientific evidence that ILE has merit in the treatment of certain poisonings, there is still uncertainty on the optimal composition of the lipid emulsion, the dosing, the mechanism of action, and the efficacy. Therefore, a critical view of the clinician on the applicability of this modality in intoxications is still warranted. The use of ILE therapy is advocated as an antidote in cases of intoxications with some lipophilic substances.

KW - Poisoning

KW - Toxin

KW - Lipid

KW - Fat

KW - Emulsion

KW - Intralipid

KW - ILE

KW - Lipid resuscitation therapy

U2 - 10.1016/j.cvsm.2016.10.018

DO - 10.1016/j.cvsm.2016.10.018

M3 - Article

C2 - 28012788

SN - 0195-5616

VL - 47

SP - 435

EP - 450

JO - Veterinary Clinics of North America - Small Animal Practice

JF - Veterinary Clinics of North America - Small Animal Practice

IS - 2

ER -

Lipid Therapy for Intoxications

Abstract

Keywords

Access to Document

Fingerprint

Cite this