Linear neutralizing epitopes on the peplomer protein of coronaviruses

W. P A Posthumus; R. H. Meloen; L. Enjuanes; I. Correa; A. P. van Nieuwstadt; G. Koch; R. J. de Groot; J. G. Kusters; W. Luytjes; W. J. Spaan; B. A M van der Zeijst; J. A. Lenstra

doi:10.1007/978-1-4684-5823-7_25

Linear neutralizing epitopes on the peplomer protein of coronaviruses

W. P A Posthumus, R. H. Meloen, L. Enjuanes, I. Correa, A. P. van Nieuwstadt, G. Koch, R. J. de Groot, J. G. Kusters, W. Luytjes, W. J. Spaan, B. A M van der Zeijst, J. A. Lenstra

Wageningen University & Research

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

Three years ago, we reported a comparison of the primary structures of the S peplomer proteins of three coronaviruses - mouse hepatitis virus (MHV, strain A59), infectious bronchitis virus (IBV, strain M41), and feline infectious peritonitis virus (FIPV, strain 79-1146) - which represent the three antigenic clusters in the Coronavirus family (De Groot et al., 1987a, b). A periodicity in the C-terminal part of the S sequence indicated the presence of a coiled-coil structure, which forms the stalk of the peplomer. The nonconserved N-terminal sequence probably forms the bulbous part of the peplomer.

Original language	English
Title of host publication	Coronaviruses and their Diseases
Publisher	Springer
Pages	181-188
Number of pages	8
DOIs	https://doi.org/10.1007/978-1-4684-5823-7_25
Publication status	Published - 1 Dec 1990

Publication series

Name	Advances in Experimental Medicine and Biology
Publisher	Springer New York
Volume	276
ISSN (Print)	0065-275X

Keywords

Infectious Bronchitis Virus
Antigenic Site
Hybrid Protein
Linear Epitope
Mouse Hepatitis Virus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-4684-5823-7_25

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Posthumus, W. P. A., Meloen, R. H., Enjuanes, L., Correa, I., van Nieuwstadt, A. P., Koch, G., de Groot, R. J., Kusters, J. G., Luytjes, W., Spaan, W. J., van der Zeijst, B. A. M., & Lenstra, J. A. (1990). Linear neutralizing epitopes on the peplomer protein of coronaviruses. In Coronaviruses and their Diseases (pp. 181-188). (Advances in Experimental Medicine and Biology; Vol. 276). Springer. https://doi.org/10.1007/978-1-4684-5823-7_25

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abstract = "Three years ago, we reported a comparison of the primary structures of the S peplomer proteins of three coronaviruses - mouse hepatitis virus (MHV, strain A59), infectious bronchitis virus (IBV, strain M41), and feline infectious peritonitis virus (FIPV, strain 79-1146) - which represent the three antigenic clusters in the Coronavirus family (De Groot et al., 1987a, b). A periodicity in the C-terminal part of the S sequence indicated the presence of a coiled-coil structure, which forms the stalk of the peplomer. The nonconserved N-terminal sequence probably forms the bulbous part of the peplomer.",

keywords = "Infectious Bronchitis Virus, Antigenic Site, Hybrid Protein, Linear Epitope, Mouse Hepatitis Virus",

author = "Posthumus, {W. P A} and Meloen, {R. H.} and L. Enjuanes and I. Correa and {van Nieuwstadt}, {A. P.} and G. Koch and {de Groot}, {R. J.} and Kusters, {J. G.} and W. Luytjes and Spaan, {W. J.} and {van der Zeijst}, {B. A M} and Lenstra, {J. A.}",

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doi = "10.1007/978-1-4684-5823-7_25",

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Posthumus, WPA, Meloen, RH, Enjuanes, L, Correa, I, van Nieuwstadt, AP, Koch, G, de Groot, RJ, Kusters, JG, Luytjes, W, Spaan, WJ, van der Zeijst, BAM & Lenstra, JA 1990, Linear neutralizing epitopes on the peplomer protein of coronaviruses. in Coronaviruses and their Diseases. Advances in Experimental Medicine and Biology, vol. 276, Springer, pp. 181-188. https://doi.org/10.1007/978-1-4684-5823-7_25

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T1 - Linear neutralizing epitopes on the peplomer protein of coronaviruses

AU - Posthumus, W. P A

AU - Meloen, R. H.

AU - Enjuanes, L.

AU - Correa, I.

AU - van Nieuwstadt, A. P.

AU - Koch, G.

AU - de Groot, R. J.

AU - Kusters, J. G.

AU - Luytjes, W.

AU - Spaan, W. J.

AU - van der Zeijst, B. A M

AU - Lenstra, J. A.

PY - 1990/12/1

Y1 - 1990/12/1

N2 - Three years ago, we reported a comparison of the primary structures of the S peplomer proteins of three coronaviruses - mouse hepatitis virus (MHV, strain A59), infectious bronchitis virus (IBV, strain M41), and feline infectious peritonitis virus (FIPV, strain 79-1146) - which represent the three antigenic clusters in the Coronavirus family (De Groot et al., 1987a, b). A periodicity in the C-terminal part of the S sequence indicated the presence of a coiled-coil structure, which forms the stalk of the peplomer. The nonconserved N-terminal sequence probably forms the bulbous part of the peplomer.

AB - Three years ago, we reported a comparison of the primary structures of the S peplomer proteins of three coronaviruses - mouse hepatitis virus (MHV, strain A59), infectious bronchitis virus (IBV, strain M41), and feline infectious peritonitis virus (FIPV, strain 79-1146) - which represent the three antigenic clusters in the Coronavirus family (De Groot et al., 1987a, b). A periodicity in the C-terminal part of the S sequence indicated the presence of a coiled-coil structure, which forms the stalk of the peplomer. The nonconserved N-terminal sequence probably forms the bulbous part of the peplomer.

KW - Infectious Bronchitis Virus

KW - Antigenic Site

KW - Hybrid Protein

KW - Linear Epitope

KW - Mouse Hepatitis Virus

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DO - 10.1007/978-1-4684-5823-7_25

M3 - Chapter

C2 - 1715660

AN - SCOPUS:0025565657

T3 - Advances in Experimental Medicine and Biology

SP - 181

EP - 188

BT - Coronaviruses and their Diseases

PB - Springer

ER -

Linear neutralizing epitopes on the peplomer protein of coronaviruses

Abstract

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Keywords

UN SDGs

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