Ligand-targeted liposomes directed against pathological vasculature

Raymond M. Schiffelers; Grietje Molema; Timo L. M. Ten Hagen; Adriënne P C A Janssen; Astrid J. Schraa; Robbert J. Kok; Gerben A. Koning; G Storm

doi:10.1081/LPR-120004785

Ligand-targeted liposomes directed against pathological vasculature

Raymond M. Schiffelers, Grietje Molema, Timo L. M. Ten Hagen, Adriënne P C A Janssen, Astrid J. Schraa, Robbert J. Kok, Gerben A. Koning, G Storm

Pharmaceutics

Dept. of Surgical Oncology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The development of liposomes targeted to angiogenic endothelial cells offers exciting prospects for intervention in cancer and inflammation. Several proteins are (strongly) over-expressed on angiogenic endothelial cells as compared to the quiescent endothelium, and could potentially serve as targets for site-specific drug delivery. In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein.

Original language	English
Pages (from-to)	129-135
Number of pages	7
Journal	Journal of Liposome Research
Volume	12
Issue number	1-2
DOIs	https://doi.org/10.1081/LPR-120004785
Publication status	Published - 11 Jan 2002

Keywords

Angiogenesis
Drug targeting
Integrins
Liposomes
RGD-peptide
angiogenesis inhibitor
arginylglycylaspartic acid
doxorubicin
integrin
ligand
liposome
malignant neoplasm
conference paper
drug delivery system
drug design
drug targeting
endothelium cell
human
human cell
inflammation
priority journal
protein expression

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10.1081/LPR-120004785

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title = "Ligand-targeted liposomes directed against pathological vasculature",

abstract = "The development of liposomes targeted to angiogenic endothelial cells offers exciting prospects for intervention in cancer and inflammation. Several proteins are (strongly) over-expressed on angiogenic endothelial cells as compared to the quiescent endothelium, and could potentially serve as targets for site-specific drug delivery. In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein.",

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year = "2002",

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doi = "10.1081/LPR-120004785",

language = "English",

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T1 - Ligand-targeted liposomes directed against pathological vasculature

AU - Schiffelers, Raymond M.

AU - Molema, Grietje

AU - Hagen, Timo L. M. Ten

AU - Janssen, Adriënne P C A

AU - Schraa, Astrid J.

AU - Kok, Robbert J.

AU - Koning, Gerben A.

AU - Storm, G

PY - 2002/1/11

Y1 - 2002/1/11

N2 - The development of liposomes targeted to angiogenic endothelial cells offers exciting prospects for intervention in cancer and inflammation. Several proteins are (strongly) over-expressed on angiogenic endothelial cells as compared to the quiescent endothelium, and could potentially serve as targets for site-specific drug delivery. In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein.

AB - The development of liposomes targeted to angiogenic endothelial cells offers exciting prospects for intervention in cancer and inflammation. Several proteins are (strongly) over-expressed on angiogenic endothelial cells as compared to the quiescent endothelium, and could potentially serve as targets for site-specific drug delivery. In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein.

KW - Angiogenesis

KW - Drug targeting

KW - Integrins

KW - Liposomes

KW - RGD-peptide

KW - angiogenesis inhibitor

KW - arginylglycylaspartic acid

KW - doxorubicin

KW - integrin

KW - ligand

KW - liposome

KW - malignant neoplasm

KW - conference paper

KW - drug delivery system

KW - drug design

KW - drug targeting

KW - endothelium cell

KW - human

KW - human cell

KW - inflammation

KW - priority journal

KW - protein expression

U2 - 10.1081/LPR-120004785

DO - 10.1081/LPR-120004785

M3 - Article

SN - 0898-2104

VL - 12

SP - 129

EP - 135

JO - Journal of Liposome Research

JF - Journal of Liposome Research

IS - 1-2

ER -

Ligand-targeted liposomes directed against pathological vasculature

Abstract

Keywords

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