Ligand-free copper-catalyzed C−S coupling of aryl iodides and thiols

E. Sperotto; G.P.M. van Klink; J.G. de Vries; G. van Koten

Ligand-free copper-catalyzed C−S coupling of aryl iodides and thiols

E. Sperotto, G.P.M. van Klink, J.G. de Vries, G. van Koten

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Abstract

A protocol for the copper-catalyzed aryl−sulfur bond formation between aryl iodides and thiophenols is reported. The reaction is catalyzed by a low amount (1−2.5 mol %) of readily available and ligand-free copper iodide salt. A variety of diaryl thioethers are synthesized under relatively mild reaction conditions with good chemoselectivity and functional group tolerance.

Original language	Undefined/Unknown
Pages (from-to)	5625-5628
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	73
Issue number	14
Publication status	Published - 2008

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Cite this

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title = "Ligand-free copper-catalyzed C−S coupling of aryl iodides and thiols",

abstract = "A protocol for the copper-catalyzed aryl−sulfur bond formation between aryl iodides and thiophenols is reported. The reaction is catalyzed by a low amount (1−2.5 mol %) of readily available and ligand-free copper iodide salt. A variety of diaryl thioethers are synthesized under relatively mild reaction conditions with good chemoselectivity and functional group tolerance.",

author = "E. Sperotto and {van Klink}, G.P.M. and {de Vries}, J.G. and {van Koten}, G.",

year = "2008",

language = "Undefined/Unknown",

volume = "73",

pages = "5625--5628",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society : Division of Carbohydrate Chemistry",

number = "14",

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T1 - Ligand-free copper-catalyzed C−S coupling of aryl iodides and thiols

AU - Sperotto, E.

AU - van Klink, G.P.M.

AU - de Vries, J.G.

AU - van Koten, G.

PY - 2008

Y1 - 2008

N2 - A protocol for the copper-catalyzed aryl−sulfur bond formation between aryl iodides and thiophenols is reported. The reaction is catalyzed by a low amount (1−2.5 mol %) of readily available and ligand-free copper iodide salt. A variety of diaryl thioethers are synthesized under relatively mild reaction conditions with good chemoselectivity and functional group tolerance.

AB - A protocol for the copper-catalyzed aryl−sulfur bond formation between aryl iodides and thiophenols is reported. The reaction is catalyzed by a low amount (1−2.5 mol %) of readily available and ligand-free copper iodide salt. A variety of diaryl thioethers are synthesized under relatively mild reaction conditions with good chemoselectivity and functional group tolerance.

M3 - Article

SN - 0022-3263

VL - 73

SP - 5625

EP - 5628

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 14

ER -