Leukotrienes mediate tracheal hyperresponsiveness after nitric oxide synthesis inhibition

G Folkerts; H Van der Linde; P G Van de Loo; F Engels; F P Nijkamp

Leukotrienes mediate tracheal hyperresponsiveness after nitric oxide synthesis inhibition

G Folkerts, H Van der Linde, P G Van de Loo, F Engels, F P Nijkamp

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Preincubation of guinea pig tracheas with the nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME, 120 microM) resulted in a significant upward shift of the histamine concentration-response curve with a concomitant inhibition of prostaglandin E2 production. Preincubation of the preparations with a 5-lipoxygenase inhibitor (AA-861, 2-(12-hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl-p-benzoquinone) or a leukotriene C4,D4,E4 receptor antagonist (FPL 55712, sodium 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxy propoxy]-4-oxo-8- propyl-4H-1-benzopyran-2-carboxylate) totally blocked the L-NAME-induced tracheal hyperresponsiveness. A shift from cyclo-oxygenase to lipoxygenase products, in particular leukotrienes, is likely to be responsible for the L-NAME-induced tracheal hyperresponsiveness.

Original language	English
Pages (from-to)	R1-2
Journal	European Journal of Pharmacology
Volume	285
Issue number	2
Publication status	Published - 1995

Keywords

Animals
Arginine
Benzoquinones
Chromones
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Guinea Pigs
In Vitro Techniques
Leukotrienes
Lipoxygenase Inhibitors
NG-Nitroarginine Methyl Ester
Nitric Oxide
Nitric Oxide Synthase
Trachea

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title = "Leukotrienes mediate tracheal hyperresponsiveness after nitric oxide synthesis inhibition",

abstract = "Preincubation of guinea pig tracheas with the nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME, 120 microM) resulted in a significant upward shift of the histamine concentration-response curve with a concomitant inhibition of prostaglandin E2 production. Preincubation of the preparations with a 5-lipoxygenase inhibitor (AA-861, 2-(12-hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl-p-benzoquinone) or a leukotriene C4,D4,E4 receptor antagonist (FPL 55712, sodium 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxy propoxy]-4-oxo-8- propyl-4H-1-benzopyran-2-carboxylate) totally blocked the L-NAME-induced tracheal hyperresponsiveness. A shift from cyclo-oxygenase to lipoxygenase products, in particular leukotrienes, is likely to be responsible for the L-NAME-induced tracheal hyperresponsiveness.",

keywords = "Animals, Arginine, Benzoquinones, Chromones, Cyclooxygenase Inhibitors, Enzyme Inhibitors, Guinea Pigs, In Vitro Techniques, Leukotrienes, Lipoxygenase Inhibitors, NG-Nitroarginine Methyl Ester, Nitric Oxide, Nitric Oxide Synthase, Trachea",

author = "G Folkerts and {Van der Linde}, H and {Van de Loo}, {P G} and F Engels and Nijkamp, {F P}",

year = "1995",

language = "English",

volume = "285",

pages = "R1--2",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier BV",

number = "2",

}

TY - JOUR

T1 - Leukotrienes mediate tracheal hyperresponsiveness after nitric oxide synthesis inhibition

AU - Folkerts, G

AU - Van der Linde, H

AU - Van de Loo, P G

AU - Engels, F

AU - Nijkamp, F P

PY - 1995

Y1 - 1995

N2 - Preincubation of guinea pig tracheas with the nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME, 120 microM) resulted in a significant upward shift of the histamine concentration-response curve with a concomitant inhibition of prostaglandin E2 production. Preincubation of the preparations with a 5-lipoxygenase inhibitor (AA-861, 2-(12-hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl-p-benzoquinone) or a leukotriene C4,D4,E4 receptor antagonist (FPL 55712, sodium 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxy propoxy]-4-oxo-8- propyl-4H-1-benzopyran-2-carboxylate) totally blocked the L-NAME-induced tracheal hyperresponsiveness. A shift from cyclo-oxygenase to lipoxygenase products, in particular leukotrienes, is likely to be responsible for the L-NAME-induced tracheal hyperresponsiveness.

AB - Preincubation of guinea pig tracheas with the nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME, 120 microM) resulted in a significant upward shift of the histamine concentration-response curve with a concomitant inhibition of prostaglandin E2 production. Preincubation of the preparations with a 5-lipoxygenase inhibitor (AA-861, 2-(12-hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl-p-benzoquinone) or a leukotriene C4,D4,E4 receptor antagonist (FPL 55712, sodium 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxy propoxy]-4-oxo-8- propyl-4H-1-benzopyran-2-carboxylate) totally blocked the L-NAME-induced tracheal hyperresponsiveness. A shift from cyclo-oxygenase to lipoxygenase products, in particular leukotrienes, is likely to be responsible for the L-NAME-induced tracheal hyperresponsiveness.

KW - Animals

KW - Arginine

KW - Benzoquinones

KW - Chromones

KW - Cyclooxygenase Inhibitors

KW - Enzyme Inhibitors

KW - Guinea Pigs

KW - In Vitro Techniques

KW - Leukotrienes

KW - Lipoxygenase Inhibitors

KW - NG-Nitroarginine Methyl Ester

KW - Nitric Oxide

KW - Nitric Oxide Synthase

KW - Trachea

M3 - Article

C2 - 8566126

SN - 0014-2999

VL - 285

SP - R1-2

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2

ER -

Leukotrienes mediate tracheal hyperresponsiveness after nitric oxide synthesis inhibition

Abstract

Keywords

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