Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers

L. Zhang; Q. Lan; Z. Ji; G. Li; M. Shen; R. Vermeulen; W. Guo; E. Hubbard; C.M. McHale; S.M. Rappaport; R.B. Hayes; M.S. Linet; S. Yin; M.T. Smith; N. Rothman

doi:10.1038/leu.2012.143

Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers

L. Zhang, Q. Lan, Z. Ji, G. Li, M. Shen, R. Vermeulen, W. Guo, E. Hubbard, C.M. McHale, S.M. Rappaport, R.B. Hayes, M.S. Linet, S. Yin, M.T. Smith, N. Rothman

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Abstract

Benzene exposure causes acute myeloid leukemia and hematotoxicity, shown as suppression of mature blood and myeloid progenitor cell numbers. As the leukemia-related aneuploidies monosomy 7 and trisomy 8 previously had been detected in the mature peripheral blood cells of exposed workers, we hypothesized that benzene could cause leukemia through the induction of these aneuploidies in hematopoietic stem and progenitor cells. We measured loss and gain of chromosomes 7 and 8 by fluorescence in situ hybridization in interphase colony-forming unit-granulocyte-macrophage (CFU-GM) cells cultured from otherwise healthy benzene-exposed (n=28) and unexposed (n=14) workers. CFU-GM monosomy 7 and 8 levels (but not trisomy) were significantly increased in subjects exposed to benzene overall, compared with levels in the control subjects (P=0.0055 and P=0.0034, respectively). Levels of monosomy 7 and 8 were significantly increased in subjects exposed to

Original language	English
Pages (from-to)	2494-2498
Number of pages	5
Journal	Leukemia
Volume	26
Issue number	12
DOIs	https://doi.org/10.1038/leu.2012.143
Publication status	Published - 2012

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title = "Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers",

abstract = "Benzene exposure causes acute myeloid leukemia and hematotoxicity, shown as suppression of mature blood and myeloid progenitor cell numbers. As the leukemia-related aneuploidies monosomy 7 and trisomy 8 previously had been detected in the mature peripheral blood cells of exposed workers, we hypothesized that benzene could cause leukemia through the induction of these aneuploidies in hematopoietic stem and progenitor cells. We measured loss and gain of chromosomes 7 and 8 by fluorescence in situ hybridization in interphase colony-forming unit-granulocyte-macrophage (CFU-GM) cells cultured from otherwise healthy benzene-exposed (n=28) and unexposed (n=14) workers. CFU-GM monosomy 7 and 8 levels (but not trisomy) were significantly increased in subjects exposed to benzene overall, compared with levels in the control subjects (P=0.0055 and P=0.0034, respectively). Levels of monosomy 7 and 8 were significantly increased in subjects exposed to",

author = "L. Zhang and Q. Lan and Z. Ji and G. Li and M. Shen and R. Vermeulen and W. Guo and E. Hubbard and C.M. McHale and S.M. Rappaport and R.B. Hayes and M.S. Linet and S. Yin and M.T. Smith and N. Rothman",

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doi = "10.1038/leu.2012.143",

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T1 - Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers

AU - Zhang, L.

AU - Lan, Q.

AU - Ji, Z.

AU - Li, G.

AU - Shen, M.

AU - Vermeulen, R.

AU - Guo, W.

AU - Hubbard, E.

AU - McHale, C.M.

AU - Rappaport, S.M.

AU - Hayes, R.B.

AU - Linet, M.S.

AU - Yin, S.

AU - Smith, M.T.

AU - Rothman, N.

PY - 2012

Y1 - 2012

N2 - Benzene exposure causes acute myeloid leukemia and hematotoxicity, shown as suppression of mature blood and myeloid progenitor cell numbers. As the leukemia-related aneuploidies monosomy 7 and trisomy 8 previously had been detected in the mature peripheral blood cells of exposed workers, we hypothesized that benzene could cause leukemia through the induction of these aneuploidies in hematopoietic stem and progenitor cells. We measured loss and gain of chromosomes 7 and 8 by fluorescence in situ hybridization in interphase colony-forming unit-granulocyte-macrophage (CFU-GM) cells cultured from otherwise healthy benzene-exposed (n=28) and unexposed (n=14) workers. CFU-GM monosomy 7 and 8 levels (but not trisomy) were significantly increased in subjects exposed to benzene overall, compared with levels in the control subjects (P=0.0055 and P=0.0034, respectively). Levels of monosomy 7 and 8 were significantly increased in subjects exposed to

AB - Benzene exposure causes acute myeloid leukemia and hematotoxicity, shown as suppression of mature blood and myeloid progenitor cell numbers. As the leukemia-related aneuploidies monosomy 7 and trisomy 8 previously had been detected in the mature peripheral blood cells of exposed workers, we hypothesized that benzene could cause leukemia through the induction of these aneuploidies in hematopoietic stem and progenitor cells. We measured loss and gain of chromosomes 7 and 8 by fluorescence in situ hybridization in interphase colony-forming unit-granulocyte-macrophage (CFU-GM) cells cultured from otherwise healthy benzene-exposed (n=28) and unexposed (n=14) workers. CFU-GM monosomy 7 and 8 levels (but not trisomy) were significantly increased in subjects exposed to benzene overall, compared with levels in the control subjects (P=0.0055 and P=0.0034, respectively). Levels of monosomy 7 and 8 were significantly increased in subjects exposed to

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DO - 10.1038/leu.2012.143

M3 - Article

SN - 0887-6924

VL - 26

SP - 2494

EP - 2498

JO - Leukemia

JF - Leukemia

IS - 12

ER -

Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers

Abstract

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