Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens: Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix

Amy L Hall; Hans Kromhout; Joachim Schüz; Susan Peters; Lützen Portengen; Roel Vermeulen; Antonio Agudo; Wolfgang Ahrens; Paolo Boffetta; Paul Brennan; Cristina Canova; David I Conway; Maria Paula Curado; Alexander W Daudt; Leticia Fernandez; Mia Hashibe; Claire M Healy; Ivana Holcatova; Kristina Kjaerheim; Rosalina Koifman; Pagona Lagiou; Danièle Luce; Gary J Macfarlane; Ana Menezes; Gwenn Menvielle; Jerry Polesel; Heribert Ramroth; Lorenzo Richiardi; Isabelle Stücker; Peter Thomson; Marta Vilensky; Victor Wunsch-Filho; Yuan-Chin Amy Lee; Ariana Znaor; Kurt Straif; Ann Olsson

doi:10.1097/EDE.0000000000001120

Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens: Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix

Amy L Hall
, Hans Kromhout
, Joachim Schüz
, Susan Peters
, Lützen Portengen
, Roel Vermeulen
, Antonio Agudo
, Wolfgang Ahrens
, Paolo Boffetta
, Paul Brennan
, Cristina Canova
, David I Conway
, Maria Paula Curado
, Alexander W Daudt
, Leticia Fernandez
, Mia Hashibe
, Claire M Healy
, Ivana Holcatova
, Kristina Kjaerheim
, Rosalina Koifman

Pagona Lagiou, Danièle Luce, Gary J Macfarlane, Ana Menezes, Gwenn Menvielle, Jerry Polesel, Heribert Ramroth, Lorenzo Richiardi, Isabelle Stücker, Peter Thomson, Marta Vilensky, Victor Wunsch-Filho, Yuan-Chin Amy Lee, Ariana Znaor, Kurt Straif, Ann Olsson

Epigenetics Group, International Agency for Research on Cancer, Lyon, France.
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
University of Padova
School of Medicine, Dentistry, and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Epidemiology - CIPE/ACCAMARGO, Sao Paulo, Brazil.
Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
Institute of Oncology and Radiobiology, Havana, Cuba.
University of Utah, Salt Lake City, Utah, USA.
Trinity College School of Dental Science, Dublin, Ireland.
Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Cancer Registry of Norway, Institute of Population-based Cancer Research, Oslo, Norway.
Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Pointe-à-Pitre, France.
Epidemiology Group, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, United Kingdom.
Universidade Federal de Pelotas, Pelotas, Brazil.
INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique IPLESP, Paris, France.
Aviano Cancer Centre, Aviano, Italy.
Heidelberg University
University Paris Sud, Paris Saclay University, UVSQ, CESP, INSERM, Environmental Epidemiology of Cancer Team, Villejuif, France.
Hong Kong University of Science and Technology
Institute of Oncology Angel H. Roffo, University of Buenos Aires, Argentina.
Universidade de São Paulo

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

INTRODUCTION: Various established occupational lung carcinogens are also suspected risk factors for laryngeal cancer. However, individual studies are often inadequate in size to investigate this relatively rare outcome. Other limitations include imprecise exposure assessment and inadequate adjustment for confounders.

METHODS: This study applied a quantitative job exposure matrix (SYN-JEM) for four established occupational lung carcinogens to five case-control studies within the INHANCE Consortium. We used occupational histories for 2256 laryngeal cancer cases and 7857 controls recruited from 1989-2007. We assigned quantitative exposure levels for asbestos, respirable crystalline silica, chromium-VI, and chromium-VI & nickel combined (to address highly correlated exposures) via SYN-JEM. We assessed effects of occupational exposure on cancer risk for males (asbestos, respirable crystalline silica, chromium-VI, chromium-VI & nickel) and females (asbestos, respirable crystalline silica), adjusting for age, study, tobacco smoking, alcohol consumption, and asbestos exposure where relevant.

RESULTS: Among females, odds ratios (ORs) were increased for ever versus never exposed. Among males, p-values for linear trend were <0.05 for estimated cumulative exposure (all agents) and <0.05 for exposure duration (respirable crystalline silica, chromium-VI, and chromium-VI & nickel); strongest associations were for asbestos at >90%ile cumulative exposure (OR=1.3, CI=1.0-1.6), respirable crystalline silica at 30+ years duration (OR=1.4, CI=1.2-1.7) and 75%-90%ile cumulative exposure (OR=1.4, CI=1.1-1.8), chromium-VI at >75%ile cumulative exposure (OR=1.9, CI=1.2-3.0), and chromium-VI & nickel at 20-29 years duration (OR=1.5, CI=1.1-2.2).

CONCLUSIONS: These findings support hypotheses of causal links between four lung carcinogens (asbestos, respirable crystalline silica, chromium-VI, and nickel) and laryngeal cancer.

Original language	English
Pages (from-to)	145-154
Number of pages	10
Journal	Epidemiology
Volume	31
Issue number	1
Early online date	2019
DOIs	https://doi.org/10.1097/EDE.0000000000001120
Publication status	Published - Jan 2020

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SDG 3 Good Health and Well-being

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10.1097/EDE.0000000000001120

Laryngeal_Cancer_Risks_in_Workers_Exposed_to_Lung.17Final published version, 137 KBLicence: Taverne

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Hall, A. L., Kromhout, H., Schüz, J., Peters, S., Portengen, L., Vermeulen, R., Agudo, A., Ahrens, W., Boffetta, P., Brennan, P., Canova, C., Conway, D. I., Curado, M. P., Daudt, A. W., Fernandez, L., Hashibe, M., Healy, C. M., Holcatova, I., Kjaerheim, K., ... Olsson, A. (2020). Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens: Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix. Epidemiology, 31(1), 145-154. https://doi.org/10.1097/EDE.0000000000001120

@article{06ef19866d9e48cb9d2ddc744e0a805c,

title = "Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens: Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix",

abstract = "INTRODUCTION: Various established occupational lung carcinogens are also suspected risk factors for laryngeal cancer. However, individual studies are often inadequate in size to investigate this relatively rare outcome. Other limitations include imprecise exposure assessment and inadequate adjustment for confounders.METHODS: This study applied a quantitative job exposure matrix (SYN-JEM) for four established occupational lung carcinogens to five case-control studies within the INHANCE Consortium. We used occupational histories for 2256 laryngeal cancer cases and 7857 controls recruited from 1989-2007. We assigned quantitative exposure levels for asbestos, respirable crystalline silica, chromium-VI, and chromium-VI \& nickel combined (to address highly correlated exposures) via SYN-JEM. We assessed effects of occupational exposure on cancer risk for males (asbestos, respirable crystalline silica, chromium-VI, chromium-VI \& nickel) and females (asbestos, respirable crystalline silica), adjusting for age, study, tobacco smoking, alcohol consumption, and asbestos exposure where relevant.RESULTS: Among females, odds ratios (ORs) were increased for ever versus never exposed. Among males, p-values for linear trend were <0.05 for estimated cumulative exposure (all agents) and <0.05 for exposure duration (respirable crystalline silica, chromium-VI, and chromium-VI \& nickel); strongest associations were for asbestos at >90\%ile cumulative exposure (OR=1.3, CI=1.0-1.6), respirable crystalline silica at 30+ years duration (OR=1.4, CI=1.2-1.7) and 75\%-90\%ile cumulative exposure (OR=1.4, CI=1.1-1.8), chromium-VI at >75\%ile cumulative exposure (OR=1.9, CI=1.2-3.0), and chromium-VI \& nickel at 20-29 years duration (OR=1.5, CI=1.1-2.2).CONCLUSIONS: These findings support hypotheses of causal links between four lung carcinogens (asbestos, respirable crystalline silica, chromium-VI, and nickel) and laryngeal cancer.",

author = "Hall, \{Amy L\} and Hans Kromhout and Joachim Sch{\"u}z and Susan Peters and L{\"u}tzen Portengen and Roel Vermeulen and Antonio Agudo and Wolfgang Ahrens and Paolo Boffetta and Paul Brennan and Cristina Canova and Conway, \{David I\} and Curado, \{Maria Paula\} and Daudt, \{Alexander W\} and Leticia Fernandez and Mia Hashibe and Healy, \{Claire M\} and Ivana Holcatova and Kristina Kjaerheim and Rosalina Koifman and Pagona Lagiou and Dani{\`e}le Luce and Macfarlane, \{Gary J\} and Ana Menezes and Gwenn Menvielle and Jerry Polesel and Heribert Ramroth and Lorenzo Richiardi and Isabelle St{\"u}cker and Peter Thomson and Marta Vilensky and Victor Wunsch-Filho and Lee, \{Yuan-Chin Amy\} and Ariana Znaor and Kurt Straif and Ann Olsson",

year = "2020",

month = jan,

doi = "10.1097/EDE.0000000000001120",

language = "English",

volume = "31",

pages = "145--154",

journal = "Epidemiology",

issn = "1044-3983",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

Hall, AL, Kromhout, H, Schüz, J, Peters, S , Portengen, L , Vermeulen, R, Agudo, A, Ahrens, W, Boffetta, P, Brennan, P, Canova, C, Conway, DI, Curado, MP, Daudt, AW, Fernandez, L, Hashibe, M, Healy, CM, Holcatova, I, Kjaerheim, K, Koifman, R, Lagiou, P, Luce, D, Macfarlane, GJ, Menezes, A, Menvielle, G, Polesel, J, Ramroth, H, Richiardi, L, Stücker, I, Thomson, P, Vilensky, M, Wunsch-Filho, V, Lee, Y-CA, Znaor, A, Straif, K & Olsson, A 2020, 'Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens: Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix', Epidemiology, vol. 31, no. 1, pp. 145-154. https://doi.org/10.1097/EDE.0000000000001120

TY - JOUR

T1 - Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens

T2 - Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix

AU - Hall, Amy L

AU - Kromhout, Hans

AU - Schüz, Joachim

AU - Peters, Susan

AU - Portengen, Lützen

AU - Vermeulen, Roel

AU - Agudo, Antonio

AU - Ahrens, Wolfgang

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Canova, Cristina

AU - Conway, David I

AU - Curado, Maria Paula

AU - Daudt, Alexander W

AU - Fernandez, Leticia

AU - Hashibe, Mia

AU - Healy, Claire M

AU - Holcatova, Ivana

AU - Kjaerheim, Kristina

AU - Koifman, Rosalina

AU - Lagiou, Pagona

AU - Luce, Danièle

AU - Macfarlane, Gary J

AU - Menezes, Ana

AU - Menvielle, Gwenn

AU - Polesel, Jerry

AU - Ramroth, Heribert

AU - Richiardi, Lorenzo

AU - Stücker, Isabelle

AU - Thomson, Peter

AU - Vilensky, Marta

AU - Wunsch-Filho, Victor

AU - Lee, Yuan-Chin Amy

AU - Znaor, Ariana

AU - Straif, Kurt

AU - Olsson, Ann

PY - 2020/1

Y1 - 2020/1

N2 - INTRODUCTION: Various established occupational lung carcinogens are also suspected risk factors for laryngeal cancer. However, individual studies are often inadequate in size to investigate this relatively rare outcome. Other limitations include imprecise exposure assessment and inadequate adjustment for confounders.METHODS: This study applied a quantitative job exposure matrix (SYN-JEM) for four established occupational lung carcinogens to five case-control studies within the INHANCE Consortium. We used occupational histories for 2256 laryngeal cancer cases and 7857 controls recruited from 1989-2007. We assigned quantitative exposure levels for asbestos, respirable crystalline silica, chromium-VI, and chromium-VI & nickel combined (to address highly correlated exposures) via SYN-JEM. We assessed effects of occupational exposure on cancer risk for males (asbestos, respirable crystalline silica, chromium-VI, chromium-VI & nickel) and females (asbestos, respirable crystalline silica), adjusting for age, study, tobacco smoking, alcohol consumption, and asbestos exposure where relevant.RESULTS: Among females, odds ratios (ORs) were increased for ever versus never exposed. Among males, p-values for linear trend were <0.05 for estimated cumulative exposure (all agents) and <0.05 for exposure duration (respirable crystalline silica, chromium-VI, and chromium-VI & nickel); strongest associations were for asbestos at >90%ile cumulative exposure (OR=1.3, CI=1.0-1.6), respirable crystalline silica at 30+ years duration (OR=1.4, CI=1.2-1.7) and 75%-90%ile cumulative exposure (OR=1.4, CI=1.1-1.8), chromium-VI at >75%ile cumulative exposure (OR=1.9, CI=1.2-3.0), and chromium-VI & nickel at 20-29 years duration (OR=1.5, CI=1.1-2.2).CONCLUSIONS: These findings support hypotheses of causal links between four lung carcinogens (asbestos, respirable crystalline silica, chromium-VI, and nickel) and laryngeal cancer.

AB - INTRODUCTION: Various established occupational lung carcinogens are also suspected risk factors for laryngeal cancer. However, individual studies are often inadequate in size to investigate this relatively rare outcome. Other limitations include imprecise exposure assessment and inadequate adjustment for confounders.METHODS: This study applied a quantitative job exposure matrix (SYN-JEM) for four established occupational lung carcinogens to five case-control studies within the INHANCE Consortium. We used occupational histories for 2256 laryngeal cancer cases and 7857 controls recruited from 1989-2007. We assigned quantitative exposure levels for asbestos, respirable crystalline silica, chromium-VI, and chromium-VI & nickel combined (to address highly correlated exposures) via SYN-JEM. We assessed effects of occupational exposure on cancer risk for males (asbestos, respirable crystalline silica, chromium-VI, chromium-VI & nickel) and females (asbestos, respirable crystalline silica), adjusting for age, study, tobacco smoking, alcohol consumption, and asbestos exposure where relevant.RESULTS: Among females, odds ratios (ORs) were increased for ever versus never exposed. Among males, p-values for linear trend were <0.05 for estimated cumulative exposure (all agents) and <0.05 for exposure duration (respirable crystalline silica, chromium-VI, and chromium-VI & nickel); strongest associations were for asbestos at >90%ile cumulative exposure (OR=1.3, CI=1.0-1.6), respirable crystalline silica at 30+ years duration (OR=1.4, CI=1.2-1.7) and 75%-90%ile cumulative exposure (OR=1.4, CI=1.1-1.8), chromium-VI at >75%ile cumulative exposure (OR=1.9, CI=1.2-3.0), and chromium-VI & nickel at 20-29 years duration (OR=1.5, CI=1.1-2.2).CONCLUSIONS: These findings support hypotheses of causal links between four lung carcinogens (asbestos, respirable crystalline silica, chromium-VI, and nickel) and laryngeal cancer.

U2 - 10.1097/EDE.0000000000001120

DO - 10.1097/EDE.0000000000001120

M3 - Article

C2 - 31577634

SN - 1044-3983

VL - 31

SP - 145

EP - 154

JO - Epidemiology

JF - Epidemiology

IS - 1

ER -

Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens: Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix

Abstract

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