Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk

R Mukherjee; M van de Kaa; J Garssen; R J Pieters; A D Kraneveld; L E M Willemsen

doi:10.1039/c8fo02376j

Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk

R Mukherjee^*
, M van de Kaa
, J Garssen
, R J Pieters
, A D Kraneveld
, L E M Willemsen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.

Original language	English
Pages (from-to)	33-37
Journal	Food & function
Volume	10
Issue number	1
DOIs	https://doi.org/10.1039/c8fo02376j
Publication status	Published - 11 Jan 2019

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c8fo02376jFinal published version, 354 KBLicence: Taverne

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title = "Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk",

abstract = "Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.",

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AU - Garssen, J

AU - Pieters, R J

AU - Kraneveld, A D

AU - Willemsen, L E M

PY - 2019/1/11

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AB - Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.

U2 - 10.1039/c8fo02376j

DO - 10.1039/c8fo02376j

M3 - Article

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SN - 2042-6496

VL - 10

SP - 33

EP - 37

JO - Food & function

JF - Food & function

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Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk

Abstract

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