Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk

R Mukherjee; M van de Kaa; J Garssen; R J Pieters; A D Kraneveld; L E M Willemsen

doi:10.1039/c8fo02376j

Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk

R Mukherjee^*, M van de Kaa, J Garssen, R J Pieters, A D Kraneveld, L E M Willemsen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.

Original language	English
Pages (from-to)	33-37
Journal	Food & function
Volume	10
Issue number	1
DOIs	https://doi.org/10.1039/c8fo02376j
Publication status	Published - 11 Jan 2019

Access to Document

10.1039/c8fo02376j

c8fo02376jFinal published version, 354 KBLicence: Taverne

Cite this

@article{0fdf8c7a9b0e443299103f601c34e73c,

title = "Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk",

abstract = "Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.",

author = "R Mukherjee and {van de Kaa}, M and J Garssen and Pieters, {R J} and Kraneveld, {A D} and Willemsen, {L E M}",

year = "2019",

month = jan,

day = "11",

doi = "10.1039/c8fo02376j",

language = "English",

volume = "10",

pages = "33--37",

journal = "Food & function",

issn = "2042-6496",

publisher = "Royal Society of Chemistry",

number = "1",

}

TY - JOUR

T1 - Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk

AU - Mukherjee, R

AU - van de Kaa, M

AU - Garssen, J

AU - Pieters, R J

AU - Kraneveld, A D

AU - Willemsen, L E M

PY - 2019/1/11

Y1 - 2019/1/11

N2 - Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.

AB - Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.

U2 - 10.1039/c8fo02376j

DO - 10.1039/c8fo02376j

M3 - Article

C2 - 30632580

SN - 2042-6496

VL - 10

SP - 33

EP - 37

JO - Food & function

JF - Food & function

IS - 1

ER -

Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk

Abstract

Access to Document

Fingerprint

Cite this