Lack of quantitative correlation between the neutralization of poliovirus and the antibody-mediated pI shift of the virions

P Brioen; A A Thomas; A Boeyé

doi:10.1099/0022-1317-66-3-609

Lack of quantitative correlation between the neutralization of poliovirus and the antibody-mediated pI shift of the virions

P Brioen, A A Thomas, A Boeyé

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The effect of mono- and polyclonal antibodies on the infectivity and pI (isoelectric pH) of type 1 poliovirus was studied. According to Mandel's hypothesis, the isoelectric pH of poliovirus should change to about pI 4 upon neutralization. However, several antibodies did not follow this rule. Moreover, when antibodies did shift the pI, no quantitative correlation existed between the extent of neutralization and the amount of poliovirus shifted to low pI.

Original language	English
Pages (from-to)	609-13
Number of pages	5
Journal	Journal of General Virology
Volume	66 ( Pt 3)
DOIs	https://doi.org/10.1099/0022-1317-66-3-609
Publication status	Published - 1985

Keywords

Antibodies, Monoclonal
Antibodies, Viral
Dose-Response Relationship, Immunologic
Isoelectric Point
Poliovirus

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10.1099/0022-1317-66-3-609

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title = "Lack of quantitative correlation between the neutralization of poliovirus and the antibody-mediated pI shift of the virions",

abstract = "The effect of mono- and polyclonal antibodies on the infectivity and pI (isoelectric pH) of type 1 poliovirus was studied. According to Mandel's hypothesis, the isoelectric pH of poliovirus should change to about pI 4 upon neutralization. However, several antibodies did not follow this rule. Moreover, when antibodies did shift the pI, no quantitative correlation existed between the extent of neutralization and the amount of poliovirus shifted to low pI.",

keywords = "Antibodies, Monoclonal, Antibodies, Viral, Dose-Response Relationship, Immunologic, Isoelectric Point, Poliovirus",

author = "P Brioen and Thomas, {A A} and A Boey{\'e}",

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doi = "10.1099/0022-1317-66-3-609",

language = "English",

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T1 - Lack of quantitative correlation between the neutralization of poliovirus and the antibody-mediated pI shift of the virions

AU - Brioen, P

AU - Thomas, A A

AU - Boeyé, A

PY - 1985

Y1 - 1985

N2 - The effect of mono- and polyclonal antibodies on the infectivity and pI (isoelectric pH) of type 1 poliovirus was studied. According to Mandel's hypothesis, the isoelectric pH of poliovirus should change to about pI 4 upon neutralization. However, several antibodies did not follow this rule. Moreover, when antibodies did shift the pI, no quantitative correlation existed between the extent of neutralization and the amount of poliovirus shifted to low pI.

AB - The effect of mono- and polyclonal antibodies on the infectivity and pI (isoelectric pH) of type 1 poliovirus was studied. According to Mandel's hypothesis, the isoelectric pH of poliovirus should change to about pI 4 upon neutralization. However, several antibodies did not follow this rule. Moreover, when antibodies did shift the pI, no quantitative correlation existed between the extent of neutralization and the amount of poliovirus shifted to low pI.

KW - Antibodies, Monoclonal

KW - Antibodies, Viral

KW - Dose-Response Relationship, Immunologic

KW - Isoelectric Point

KW - Poliovirus

U2 - 10.1099/0022-1317-66-3-609

DO - 10.1099/0022-1317-66-3-609

M3 - Article

C2 - 2983003

SN - 0022-1317

VL - 66 ( Pt 3)

SP - 609

EP - 613

JO - Journal of General Virology

JF - Journal of General Virology

ER -

Lack of quantitative correlation between the neutralization of poliovirus and the antibody-mediated pI shift of the virions

Abstract

Keywords

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