Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations.

E. Ekelund; M. Bradley; S. Weidinger; D.L. Jovanovic; C. Johansson; C.M. Lindgren; A. Todorova; T. Jakob; T. Illig; E. von Mutius; C. Braun-Fahrlander; G. Doekes; T. Riedler; A. Scheynius; G. Pershagen; I. Kockum; J. Kere

Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations.

E. Ekelund, M. Bradley, S. Weidinger, D.L. Jovanovic, C. Johansson, C.M. Lindgren, A. Todorova, T. Jakob, T. Illig, E. von Mutius, C. Braun-Fahrlander, G. Doekes, T. Riedler, A. Scheynius, G. Pershagen, I. Kockum, J. Kere

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Eczema is often associated with development of allergic asthma. The Neuropeptide S Receptor 1 (NPSR1) gene has previously been associated with asthma and elevated serum IgE levels. The aim of this study was to investigate a potential association between the NPSR1 gene and eczema in patients and healthy individuals from five different populations in Western Europe, in total 6275 individuals. Seven single nucleotide polymorphisms previously associated with allergic asthma were genotyped. The protein expression of NPSR1 in the skin was studied using immunohistochemistry in six eczema patients and eight healthy individuals. No association was found be tween eczema and the seven single nucleotide polymor phisms in NPSR1 in any of the populations, either independently or in combinations. In addition, no difference was detected in epidermal NPSR1 expression between eczema patients and healthy individuals. These results strongly suggest that NPSR1 is not involved in the pathogenesis of eczema.

Original language	Undefined/Unknown
Pages (from-to)	115-121
Number of pages	7
Journal	Acta Dermato-Venereologica
Volume	89
Issue number	2
Publication status	Published - 2009

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Ekelund-Acta Derm Venereol 2009 89 115-121
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Cite this

Ekelund, E., Bradley, M., Weidinger, S., Jovanovic, D. L., Johansson, C., Lindgren, C. M., Todorova, A., Jakob, T., Illig, T., von Mutius, E., Braun-Fahrlander, C., Doekes, G., Riedler, T., Scheynius, A., Pershagen, G., Kockum, I., & Kere, J. (2009). Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations. Acta Dermato-Venereologica, 89(2), 115-121.

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title = "Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations.",

abstract = "Eczema is often associated with development of allergic asthma. The Neuropeptide S Receptor 1 (NPSR1) gene has previously been associated with asthma and elevated serum IgE levels. The aim of this study was to investigate a potential association between the NPSR1 gene and eczema in patients and healthy individuals from five different populations in Western Europe, in total 6275 individuals. Seven single nucleotide polymorphisms previously associated with allergic asthma were genotyped. The protein expression of NPSR1 in the skin was studied using immunohistochemistry in six eczema patients and eight healthy individuals. No association was found be tween eczema and the seven single nucleotide polymor phisms in NPSR1 in any of the populations, either independently or in combinations. In addition, no difference was detected in epidermal NPSR1 expression between eczema patients and healthy individuals. These results strongly suggest that NPSR1 is not involved in the pathogenesis of eczema.",

author = "E. Ekelund and M. Bradley and S. Weidinger and D.L. Jovanovic and C. Johansson and C.M. Lindgren and A. Todorova and T. Jakob and T. Illig and {von Mutius}, E. and C. Braun-Fahrlander and G. Doekes and T. Riedler and A. Scheynius and G. Pershagen and I. Kockum and J. Kere",

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Ekelund, E, Bradley, M, Weidinger, S, Jovanovic, DL, Johansson, C, Lindgren, CM, Todorova, A, Jakob, T, Illig, T, von Mutius, E, Braun-Fahrlander, C, Doekes, G, Riedler, T, Scheynius, A, Pershagen, G, Kockum, I & Kere, J 2009, 'Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations.', Acta Dermato-Venereologica, vol. 89, no. 2, pp. 115-121.

TY - JOUR

T1 - Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations.

AU - Ekelund, E.

AU - Bradley, M.

AU - Weidinger, S.

AU - Jovanovic, D.L.

AU - Johansson, C.

AU - Lindgren, C.M.

AU - Todorova, A.

AU - Jakob, T.

AU - Illig, T.

AU - von Mutius, E.

AU - Braun-Fahrlander, C.

AU - Doekes, G.

AU - Riedler, T.

AU - Scheynius, A.

AU - Pershagen, G.

AU - Kockum, I.

AU - Kere, J.

PY - 2009

Y1 - 2009

N2 - Eczema is often associated with development of allergic asthma. The Neuropeptide S Receptor 1 (NPSR1) gene has previously been associated with asthma and elevated serum IgE levels. The aim of this study was to investigate a potential association between the NPSR1 gene and eczema in patients and healthy individuals from five different populations in Western Europe, in total 6275 individuals. Seven single nucleotide polymorphisms previously associated with allergic asthma were genotyped. The protein expression of NPSR1 in the skin was studied using immunohistochemistry in six eczema patients and eight healthy individuals. No association was found be tween eczema and the seven single nucleotide polymor phisms in NPSR1 in any of the populations, either independently or in combinations. In addition, no difference was detected in epidermal NPSR1 expression between eczema patients and healthy individuals. These results strongly suggest that NPSR1 is not involved in the pathogenesis of eczema.

AB - Eczema is often associated with development of allergic asthma. The Neuropeptide S Receptor 1 (NPSR1) gene has previously been associated with asthma and elevated serum IgE levels. The aim of this study was to investigate a potential association between the NPSR1 gene and eczema in patients and healthy individuals from five different populations in Western Europe, in total 6275 individuals. Seven single nucleotide polymorphisms previously associated with allergic asthma were genotyped. The protein expression of NPSR1 in the skin was studied using immunohistochemistry in six eczema patients and eight healthy individuals. No association was found be tween eczema and the seven single nucleotide polymor phisms in NPSR1 in any of the populations, either independently or in combinations. In addition, no difference was detected in epidermal NPSR1 expression between eczema patients and healthy individuals. These results strongly suggest that NPSR1 is not involved in the pathogenesis of eczema.

M3 - Article

SN - 0001-5555

VL - 89

SP - 115

EP - 121

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

IS - 2

ER -