Abstract
The aim of this in vivo study was to examine the biomechanical suitability of four different bone graft substitutes in a segmental mid-diaphyseal tibia defect model in sheep. The period of the study was twelve weeks. A standardized 1 cm bone segment was isolated due to osteotomy. The bone was stabilized using a LC-DCP plate osteosynthesis and a cast bandage. After the investigation period intact and the defect tibia were extracted bilaterally and biomechanical tests were performed. The study population of 30 sheep was distributed randomized in 5 groups (n=6). A new composite consisting of a biphasic ceramic (TRICOS®) that was embedded in a fibrin matrix with TGplPTH1-34 (Parathyroid hormone) was opposed to BMP-2 (Bone morphogenic protein). Further groups were fibrin matrix with addition of TGplPTH1-34, autologous spongiosa as a positive control group and a biphasic ceramic embedded in fibrin matrix (TRICOS®) as a negative control group. Results from macroscopic, radiographic and biomechanical investigations where compared. This study could prove that with short healing times BMP-2 shows markedly better biomechanical results. Defects being filled with BMP-2 have shown a rapid induction of periosteal bridging what leads to a satisfactory primary stability of the fracture site. In contrast TRICOS® with TGplPTH1-34, fibrin matrix with TGplPTH1-34, and the negative control group have shown primary endosteal healing which couldn’t obtain sufficient torsion stability. Keywords: Biomaterials, biomechanical tests, tibial defect, sheep model
Translated title of the contribution | Biomaterials for fracture healing of a 1cm tibial bone defect - a biomechanical in vivo study in sheep |
---|---|
Original language | German |
Type | Thesis |
Media of output | monographic publication |
Number of pages | 90 |
Place of Publication | Vetsuisse-Fakultät Universität Zürich |
Publication status | Published - 2013 |
Externally published | Yes |