Knochenersatzstoffe fur einen 1 cm Knochendefekt in der Tibia : eine biomechanische In-vivo-Studie in Schafen

Translated title of the contribution: Biomaterials for fracture healing of a 1cm tibial bone defect - a biomechanical in vivo study in sheep

T.P. Dobak, Brigitte von Rechenberg, Stephen J. Ferguson

Research output: Other contributionOther research output

Abstract

The aim of this in vivo study was to examine the biomechanical suitability of four different bone graft substitutes in a segmental mid-diaphyseal tibia defect model in sheep. The period of the study was twelve weeks. A standardized 1 cm bone segment was isolated due to osteotomy. The bone was stabilized using a LC-DCP plate osteosynthesis and a cast bandage. After the investigation period intact and the defect tibia were extracted bilaterally and biomechanical tests were performed. The study population of 30 sheep was distributed randomized in 5 groups (n=6). A new composite consisting of a biphasic ceramic (TRICOS®) that was embedded in a fibrin matrix with TGplPTH1-34 (Parathyroid hormone) was opposed to BMP-2 (Bone morphogenic protein). Further groups were fibrin matrix with addition of TGplPTH1-34, autologous spongiosa as a positive control group and a biphasic ceramic embedded in fibrin matrix (TRICOS®) as a negative control group. Results from macroscopic, radiographic and biomechanical investigations where compared. This study could prove that with short healing times BMP-2 shows markedly better biomechanical results. Defects being filled with BMP-2 have shown a rapid induction of periosteal bridging what leads to a satisfactory primary stability of the fracture site. In contrast TRICOS® with TGplPTH1-34, fibrin matrix with TGplPTH1-34, and the negative control group have shown primary endosteal healing which couldn’t obtain sufficient torsion stability. Keywords: Biomaterials, biomechanical tests, tibial defect, sheep model
Translated title of the contributionBiomaterials for fracture healing of a 1cm tibial bone defect - a biomechanical in vivo study in sheep
Original languageGerman
TypeThesis
Media of outputmonographic publication
Number of pages90
Place of PublicationVetsuisse-Fakultät Universität Zürich
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Dive into the research topics of 'Biomaterials for fracture healing of a 1cm tibial bone defect - a biomechanical in vivo study in sheep'. Together they form a unique fingerprint.

Cite this