Abstract
Chronic kidney disease (CKD) is a global health problem with significant morbidity and mortality. Currently, the only two therapeutic options offered to patients are dialysis and renal transplantation, but each with significant limitations. There is a critical need for improved model systems to study renal tissue repair or predict drug efficacy and safety. Recent advances in tissue culture systems acknowledge the importance of the tissue microenvironment in optimal functioning and responsiveness. Communication between cells is essential as well as biomechanic and chemotactic processes, which influence cell proliferation, migration, and differentiation processes. These processes are advanced when tissues are cultured in 3D-platforms and under continuous flow conditions. This chapter gives an overview of innovative technologies related to 3D kidney cell cultures. Examples of three technologies (hollow fiber membranes, gel-based systems, and microfluidics) will be discussed with respect to their suitability in studying pharmacological and therapeutic approaches in regenerative nephrology.
| Original language | English |
|---|---|
| Title of host publication | Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era |
| Place of Publication | London |
| Publisher | Elsevier |
| Pages | 1119-1133 |
| Number of pages | 15 |
| ISBN (Electronic) | 9780128018361 |
| ISBN (Print) | 9780128017340 |
| DOIs | |
| Publication status | Published - 6 Jul 2017 |
Keywords
- Bioartifical kidney
- Disease modeling
- Gel-based systems
- Hollow fiber membranes
- Kidney bioengineering
- Kidney disease
- Microfluidics
- Nephrotoxicity
- Organ-on-chip technology
- Regenerative pharmacology