Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts

Marie Pedersen; Massimo Stafoggia; Gudrun Weinmayr; Zorana J. Andersen; Claudia Galassi; Johan N. Sommar; Bertil Forsberg; David Olsson; Bente Oftedal; Norun H Krog; Geir Aamodt; Andrei Pyko; Göran Pershagen; Michal Korek; Ulf de Faire; Nancy L. Pedersen; Claes Göran Östenson; Laura Fratiglioni; Mette Sørensen; Kirsten T. Eriksen; Anne Tjønneland; Petra H. Peeters; H. Bas Bueno-de-Mesquita; Roel Vermeulen; Marloes Eeftens; Michelle Plusquin; Timothy J. Key; Andrea Jaensch; Gabriele Nagel; Hans Concin; Meng Wang; Ming-Yi Tsai; Sara Grioni; Alessandro Marcon; Vittorio Krogh; Fulvio Ricceri; Carlotta Sacerdote; Andrea Ranzi; Giulia Cesaroni; Francesco Forastiere; Ibon Tamayo; Pilar Amiano; Miren Dorronsoro; Leslie T Stayner; Manolis Kogevinas; Mark J Nieuwenhuijsen; Ranjeet S. Sokhi; Kees de Hoogh; Rob Beelen; Paolo Vineis; Bert Brunekreef; Gerard Hoek; Ole Raaschou-Nielsen

doi:10.1016/j.euf.2016.11.008

Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts

Marie Pedersen
, Massimo Stafoggia
, Gudrun Weinmayr
, Zorana J. Andersen
, Claudia Galassi
, Johan N. Sommar
, Bertil Forsberg
, David Olsson
, Bente Oftedal
, Norun H Krog
, Geir Aamodt
, Andrei Pyko
, Göran Pershagen
, Michal Korek
, Ulf de Faire
, Nancy L. Pedersen
, Claes Göran Östenson
, Laura Fratiglioni
, Mette Sørensen
, Kirsten T. Eriksen

Anne Tjønneland, Petra H. Peeters, H. Bas Bueno-de-Mesquita, Roel Vermeulen, Marloes Eeftens, Michelle Plusquin, Timothy J. Key, Andrea Jaensch, Gabriele Nagel, Hans Concin, Meng Wang, Ming-Yi Tsai, Sara Grioni, Alessandro Marcon, Vittorio Krogh, Fulvio Ricceri, Carlotta Sacerdote, Andrea Ranzi, Giulia Cesaroni, Francesco Forastiere, Ibon Tamayo, Pilar Amiano, Miren Dorronsoro, Leslie T Stayner, Manolis Kogevinas, Mark J Nieuwenhuijsen, Ranjeet S. Sokhi, Kees de Hoogh, Rob Beelen, Paolo Vineis, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Ambient air pollution contains low concentrations of carcinogens implicated in the etiology of urinary bladder cancer (BC). Little is known about whether exposure to air pollution influences BC in the general population.

OBJECTIVE: To evaluate the association between long-term exposure to ambient air pollution and BC incidence.

DESIGN, SETTING, AND PARTICIPANTS: We obtained data from 15 population-based cohorts enrolled between 1985 and 2005 in eight European countries (N=303431; mean follow-up 14.1 yr). We estimated exposure to nitrogen oxides (NO2 and NOx), particulate matter (PM) with diameter <10μm (PM10), <2.5μm (PM2.5), between 2.5 and 10μm (PM2.5-10), PM2.5absorbance (soot), elemental constituents of PM, organic carbon, and traffic density at baseline home addresses using standardized land-use regression models from the European Study of Cohorts for Air Pollution Effects project.

OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We used Cox proportional-hazards models with adjustment for potential confounders for cohort-specific analyses and meta-analyses to estimate summary hazard ratios (HRs) for BC incidence.

RESULTS AND LIMITATIONS: During follow-up, 943 incident BC cases were diagnosed. In the meta-analysis, none of the exposures were associated with BC risk. The summary HRs associated with a 10-μg/m(3) increase in NO2 and 5-μg/m(3) increase in PM2.5 were 0.98 (95% confidence interval [CI] 0.89-1.08) and 0.86 (95% CI 0.63-1.18), respectively. Limitations include the lack of information about lifetime exposure.

CONCLUSIONS: There was no evidence of an association between exposure to outdoor air pollution levels at place of residence and risk of BC.

PATIENT SUMMARY: We assessed the link between outdoor air pollution at place of residence and bladder cancer using the largest study population to date and extensive assessment of exposure and comprehensive data on personal risk factors such as smoking. We found no association between the levels of outdoor air pollution at place of residence and bladder cancer risk.

Original language	English
Pages (from-to)	113-120
Number of pages	8
Journal	European Urology Focus
Volume	4
Issue number	1
Early online date	26 Nov 2016
DOIs	https://doi.org/10.1016/j.euf.2016.11.008
Publication status	Published - Jan 2018

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10.1016/j.euf.2016.11.008

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Pedersen, M., Stafoggia, M., Weinmayr, G., Andersen, Z. J., Galassi, C., Sommar, J. N., Forsberg, B., Olsson, D., Oftedal, B., Krog, N. H., Aamodt, G., Pyko, A., Pershagen, G., Korek, M., de Faire, U., Pedersen, N. L., Östenson, C. G., Fratiglioni, L., Sørensen, M., ... Raaschou-Nielsen, O. (2018). Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts. European Urology Focus, 4(1), 113-120. https://doi.org/10.1016/j.euf.2016.11.008

@article{9d2370cdb7e641e3b601ceb2ee14a083,

title = "Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts",

abstract = "BACKGROUND: Ambient air pollution contains low concentrations of carcinogens implicated in the etiology of urinary bladder cancer (BC). Little is known about whether exposure to air pollution influences BC in the general population.OBJECTIVE: To evaluate the association between long-term exposure to ambient air pollution and BC incidence.DESIGN, SETTING, AND PARTICIPANTS: We obtained data from 15 population-based cohorts enrolled between 1985 and 2005 in eight European countries (N=303431; mean follow-up 14.1 yr). We estimated exposure to nitrogen oxides (NO2 and NOx), particulate matter (PM) with diameter <10μm (PM10), <2.5μm (PM2.5), between 2.5 and 10μm (PM2.5-10), PM2.5absorbance (soot), elemental constituents of PM, organic carbon, and traffic density at baseline home addresses using standardized land-use regression models from the European Study of Cohorts for Air Pollution Effects project.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We used Cox proportional-hazards models with adjustment for potential confounders for cohort-specific analyses and meta-analyses to estimate summary hazard ratios (HRs) for BC incidence.RESULTS AND LIMITATIONS: During follow-up, 943 incident BC cases were diagnosed. In the meta-analysis, none of the exposures were associated with BC risk. The summary HRs associated with a 10-μg/m(3) increase in NO2 and 5-μg/m(3) increase in PM2.5 were 0.98 (95\% confidence interval [CI] 0.89-1.08) and 0.86 (95\% CI 0.63-1.18), respectively. Limitations include the lack of information about lifetime exposure.CONCLUSIONS: There was no evidence of an association between exposure to outdoor air pollution levels at place of residence and risk of BC.PATIENT SUMMARY: We assessed the link between outdoor air pollution at place of residence and bladder cancer using the largest study population to date and extensive assessment of exposure and comprehensive data on personal risk factors such as smoking. We found no association between the levels of outdoor air pollution at place of residence and bladder cancer risk.",

author = "Marie Pedersen and Massimo Stafoggia and Gudrun Weinmayr and Andersen, \{Zorana J.\} and Claudia Galassi and Sommar, \{Johan N.\} and Bertil Forsberg and David Olsson and Bente Oftedal and Krog, \{Norun H\} and Geir Aamodt and Andrei Pyko and G{\"o}ran Pershagen and Michal Korek and \{de Faire\}, Ulf and Pedersen, \{Nancy L.\} and {\"O}stenson, \{Claes G{\"o}ran\} and Laura Fratiglioni and Mette S{\o}rensen and Eriksen, \{Kirsten T.\} and Anne Tj{\o}nneland and Peeters, \{Petra H.\} and Bueno-de-Mesquita, \{H. Bas\} and Roel Vermeulen and Marloes Eeftens and Michelle Plusquin and Key, \{Timothy J.\} and Andrea Jaensch and Gabriele Nagel and Hans Concin and Meng Wang and Ming-Yi Tsai and Sara Grioni and Alessandro Marcon and Vittorio Krogh and Fulvio Ricceri and Carlotta Sacerdote and Andrea Ranzi and Giulia Cesaroni and Francesco Forastiere and Ibon Tamayo and Pilar Amiano and Miren Dorronsoro and Stayner, \{Leslie T\} and Manolis Kogevinas and Nieuwenhuijsen, \{Mark J\} and Sokhi, \{Ranjeet S.\} and \{de Hoogh\}, Kees and Rob Beelen and Paolo Vineis and Bert Brunekreef and Gerard Hoek and Ole Raaschou-Nielsen",

year = "2018",

month = jan,

doi = "10.1016/j.euf.2016.11.008",

language = "English",

volume = "4",

pages = "113--120",

journal = "European Urology Focus",

issn = "2405-4569",

publisher = "Elsevier BV",

number = "1",

}

Pedersen, M, Stafoggia, M, Weinmayr, G, Andersen, ZJ, Galassi, C, Sommar, JN, Forsberg, B, Olsson, D, Oftedal, B, Krog, NH, Aamodt, G, Pyko, A, Pershagen, G, Korek, M, de Faire, U, Pedersen, NL, Östenson, CG, Fratiglioni, L, Sørensen, M, Eriksen, KT, Tjønneland, A, Peeters, PH, Bueno-de-Mesquita, HB, Vermeulen, R, Eeftens, M, Plusquin, M, Key, TJ, Jaensch, A, Nagel, G, Concin, H, Wang, M, Tsai, M-Y, Grioni, S, Marcon, A, Krogh, V, Ricceri, F, Sacerdote, C, Ranzi, A, Cesaroni, G, Forastiere, F, Tamayo, I, Amiano, P, Dorronsoro, M, Stayner, LT, Kogevinas, M, Nieuwenhuijsen, MJ, Sokhi, RS, de Hoogh, K, Beelen, R, Vineis, P, Brunekreef, B , Hoek, G & Raaschou-Nielsen, O 2018, 'Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts', European Urology Focus, vol. 4, no. 1, pp. 113-120. https://doi.org/10.1016/j.euf.2016.11.008

TY - JOUR

T1 - Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts

AU - Pedersen, Marie

AU - Stafoggia, Massimo

AU - Weinmayr, Gudrun

AU - Andersen, Zorana J.

AU - Galassi, Claudia

AU - Sommar, Johan N.

AU - Forsberg, Bertil

AU - Olsson, David

AU - Oftedal, Bente

AU - Krog, Norun H

AU - Aamodt, Geir

AU - Pyko, Andrei

AU - Pershagen, Göran

AU - Korek, Michal

AU - de Faire, Ulf

AU - Pedersen, Nancy L.

AU - Östenson, Claes Göran

AU - Fratiglioni, Laura

AU - Sørensen, Mette

AU - Eriksen, Kirsten T.

AU - Tjønneland, Anne

AU - Peeters, Petra H.

AU - Bueno-de-Mesquita, H. Bas

AU - Vermeulen, Roel

AU - Eeftens, Marloes

AU - Plusquin, Michelle

AU - Key, Timothy J.

AU - Jaensch, Andrea

AU - Nagel, Gabriele

AU - Concin, Hans

AU - Wang, Meng

AU - Tsai, Ming-Yi

AU - Grioni, Sara

AU - Marcon, Alessandro

AU - Krogh, Vittorio

AU - Ricceri, Fulvio

AU - Sacerdote, Carlotta

AU - Ranzi, Andrea

AU - Cesaroni, Giulia

AU - Forastiere, Francesco

AU - Tamayo, Ibon

AU - Amiano, Pilar

AU - Dorronsoro, Miren

AU - Stayner, Leslie T

AU - Kogevinas, Manolis

AU - Nieuwenhuijsen, Mark J

AU - Sokhi, Ranjeet S.

AU - de Hoogh, Kees

AU - Beelen, Rob

AU - Vineis, Paolo

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Raaschou-Nielsen, Ole

PY - 2018/1

Y1 - 2018/1

N2 - BACKGROUND: Ambient air pollution contains low concentrations of carcinogens implicated in the etiology of urinary bladder cancer (BC). Little is known about whether exposure to air pollution influences BC in the general population.OBJECTIVE: To evaluate the association between long-term exposure to ambient air pollution and BC incidence.DESIGN, SETTING, AND PARTICIPANTS: We obtained data from 15 population-based cohorts enrolled between 1985 and 2005 in eight European countries (N=303431; mean follow-up 14.1 yr). We estimated exposure to nitrogen oxides (NO2 and NOx), particulate matter (PM) with diameter <10μm (PM10), <2.5μm (PM2.5), between 2.5 and 10μm (PM2.5-10), PM2.5absorbance (soot), elemental constituents of PM, organic carbon, and traffic density at baseline home addresses using standardized land-use regression models from the European Study of Cohorts for Air Pollution Effects project.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We used Cox proportional-hazards models with adjustment for potential confounders for cohort-specific analyses and meta-analyses to estimate summary hazard ratios (HRs) for BC incidence.RESULTS AND LIMITATIONS: During follow-up, 943 incident BC cases were diagnosed. In the meta-analysis, none of the exposures were associated with BC risk. The summary HRs associated with a 10-μg/m(3) increase in NO2 and 5-μg/m(3) increase in PM2.5 were 0.98 (95% confidence interval [CI] 0.89-1.08) and 0.86 (95% CI 0.63-1.18), respectively. Limitations include the lack of information about lifetime exposure.CONCLUSIONS: There was no evidence of an association between exposure to outdoor air pollution levels at place of residence and risk of BC.PATIENT SUMMARY: We assessed the link between outdoor air pollution at place of residence and bladder cancer using the largest study population to date and extensive assessment of exposure and comprehensive data on personal risk factors such as smoking. We found no association between the levels of outdoor air pollution at place of residence and bladder cancer risk.

AB - BACKGROUND: Ambient air pollution contains low concentrations of carcinogens implicated in the etiology of urinary bladder cancer (BC). Little is known about whether exposure to air pollution influences BC in the general population.OBJECTIVE: To evaluate the association between long-term exposure to ambient air pollution and BC incidence.DESIGN, SETTING, AND PARTICIPANTS: We obtained data from 15 population-based cohorts enrolled between 1985 and 2005 in eight European countries (N=303431; mean follow-up 14.1 yr). We estimated exposure to nitrogen oxides (NO2 and NOx), particulate matter (PM) with diameter <10μm (PM10), <2.5μm (PM2.5), between 2.5 and 10μm (PM2.5-10), PM2.5absorbance (soot), elemental constituents of PM, organic carbon, and traffic density at baseline home addresses using standardized land-use regression models from the European Study of Cohorts for Air Pollution Effects project.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We used Cox proportional-hazards models with adjustment for potential confounders for cohort-specific analyses and meta-analyses to estimate summary hazard ratios (HRs) for BC incidence.RESULTS AND LIMITATIONS: During follow-up, 943 incident BC cases were diagnosed. In the meta-analysis, none of the exposures were associated with BC risk. The summary HRs associated with a 10-μg/m(3) increase in NO2 and 5-μg/m(3) increase in PM2.5 were 0.98 (95% confidence interval [CI] 0.89-1.08) and 0.86 (95% CI 0.63-1.18), respectively. Limitations include the lack of information about lifetime exposure.CONCLUSIONS: There was no evidence of an association between exposure to outdoor air pollution levels at place of residence and risk of BC.PATIENT SUMMARY: We assessed the link between outdoor air pollution at place of residence and bladder cancer using the largest study population to date and extensive assessment of exposure and comprehensive data on personal risk factors such as smoking. We found no association between the levels of outdoor air pollution at place of residence and bladder cancer risk.

U2 - 10.1016/j.euf.2016.11.008

DO - 10.1016/j.euf.2016.11.008

M3 - Article

C2 - 28753823

SN - 2405-4569

VL - 4

SP - 113

EP - 120

JO - European Urology Focus

JF - European Urology Focus

IS - 1

ER -

Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts

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