Iodonium Ion Promoted Cyclization: A Convenient Approach to Glycosyl Donors of 3-Deoxy-D-manno-2-octulosonic Acid (KDO)

Pieter A.M. Van Der Klein, Geert J.P.H. Boons, Gerrit H. Veeneman, Gijs A. Van Der Marel, Jacques H. Van Boom

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Cyclization of methyl 3-deoxy-4,5:7,8-di-O-isopropylidene-D-manno-octulonate diethyl dithioacetal with iodonium sym-dicollidine perchlorate or N-iodosuccinimide yields methyl 2,3-dideoxy-4,5:7,8-di-O-isopropylidene-D-manno-oct-2-enulosonate (KDO-glycal) or the ethyl 2-thio-α-glycoside of 3-deoxy-D-manno-2-octulosonic acid, respectively. The latter compounds can be employed as glycosyl donors of 3-deoxy-D-manno-2-octulosonic acid.

Original languageEnglish
Pages (from-to)311-313
Number of pages3
JournalSynlett
Volume1990
Issue number6
DOIs
Publication statusPublished - 1 Jun 1990
Externally publishedYes

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