INVOLVEMENT OF HYPOTHALAMIC SEROTONIN IN ACTIVATION OF THE SYMPATHOADRENOMEDULLARY SYSTEM AND HYPOTHALAMO-PITUITARY-ADRENOCORTICAL AXIS IN MALE WISTAR RATS

SM KORTE; S VANDUIN; GAH BOUWS; JM KOOLHAAS; B BOHUS; Mechiel Korte

INVOLVEMENT OF HYPOTHALAMIC SEROTONIN IN ACTIVATION OF THE SYMPATHOADRENOMEDULLARY SYSTEM AND HYPOTHALAMO-PITUITARY-ADRENOCORTICAL AXIS IN MALE WISTAR RATS

SM KORTE^*, S VANDUIN, GAH BOUWS, JM KOOLHAAS, B BOHUS, Mechiel Korte

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Abstract

Infusion of the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (2.5-20-mu-g in 1-mu-l during 15 min), into the paraventricular nucleus of the hypothalamus (PVN) in the rat dose dependently increased plasma adrenaline and corticosterone concentrations, without affecting plasma noradrenaline concentrations. The highest dose also increased plasma glucose levels significantly. The results suggest that both the sympathoadrenomedullary system and the hypothalamo-pituitary-adrenocortical axis are activated after stimulation of 5-HT1A receptors in the PVN.

Original language	English
Pages (from-to)	225-228
Number of pages	4
Journal	European Journal of Pharmacology
Volume	197
Issue number	2-3
Publication status	Published - 17 May 1991

Keywords

5-HT1A RECEPTORS
PARAVENTRICULAR NUCLEUS
ADRENALINE
CORTICOSTERONE
IPSAPIRONE
RECEPTORS
8-OH-DPAT
RESPONSES
SECRETION
NUCLEUS

Cite this

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title = "INVOLVEMENT OF HYPOTHALAMIC SEROTONIN IN ACTIVATION OF THE SYMPATHOADRENOMEDULLARY SYSTEM AND HYPOTHALAMO-PITUITARY-ADRENOCORTICAL AXIS IN MALE WISTAR RATS",

abstract = "Infusion of the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (2.5-20-mu-g in 1-mu-l during 15 min), into the paraventricular nucleus of the hypothalamus (PVN) in the rat dose dependently increased plasma adrenaline and corticosterone concentrations, without affecting plasma noradrenaline concentrations. The highest dose also increased plasma glucose levels significantly. The results suggest that both the sympathoadrenomedullary system and the hypothalamo-pituitary-adrenocortical axis are activated after stimulation of 5-HT1A receptors in the PVN.",

keywords = "5-HT1A RECEPTORS, PARAVENTRICULAR NUCLEUS, ADRENALINE, CORTICOSTERONE, IPSAPIRONE, RECEPTORS, 8-OH-DPAT, RESPONSES, SECRETION, NUCLEUS",

author = "SM KORTE and S VANDUIN and GAH BOUWS and JM KOOLHAAS and B BOHUS and Mechiel Korte",

year = "1991",

month = may,

day = "17",

language = "English",

volume = "197",

pages = "225--228",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier BV",

number = "2-3",

}

INVOLVEMENT OF HYPOTHALAMIC SEROTONIN IN ACTIVATION OF THE SYMPATHOADRENOMEDULLARY SYSTEM AND HYPOTHALAMO-PITUITARY-ADRENOCORTICAL AXIS IN MALE WISTAR RATS. / KORTE, SM; VANDUIN, S; BOUWS, GAH et al.
In: European Journal of Pharmacology, Vol. 197, No. 2-3, 17.05.1991, p. 225-228.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

TY - JOUR

T1 - INVOLVEMENT OF HYPOTHALAMIC SEROTONIN IN ACTIVATION OF THE SYMPATHOADRENOMEDULLARY SYSTEM AND HYPOTHALAMO-PITUITARY-ADRENOCORTICAL AXIS IN MALE WISTAR RATS

AU - KORTE, SM

AU - VANDUIN, S

AU - BOUWS, GAH

AU - KOOLHAAS, JM

AU - BOHUS, B

AU - Korte, Mechiel

PY - 1991/5/17

Y1 - 1991/5/17

N2 - Infusion of the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (2.5-20-mu-g in 1-mu-l during 15 min), into the paraventricular nucleus of the hypothalamus (PVN) in the rat dose dependently increased plasma adrenaline and corticosterone concentrations, without affecting plasma noradrenaline concentrations. The highest dose also increased plasma glucose levels significantly. The results suggest that both the sympathoadrenomedullary system and the hypothalamo-pituitary-adrenocortical axis are activated after stimulation of 5-HT1A receptors in the PVN.

AB - Infusion of the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (2.5-20-mu-g in 1-mu-l during 15 min), into the paraventricular nucleus of the hypothalamus (PVN) in the rat dose dependently increased plasma adrenaline and corticosterone concentrations, without affecting plasma noradrenaline concentrations. The highest dose also increased plasma glucose levels significantly. The results suggest that both the sympathoadrenomedullary system and the hypothalamo-pituitary-adrenocortical axis are activated after stimulation of 5-HT1A receptors in the PVN.

KW - 5-HT1A RECEPTORS

KW - PARAVENTRICULAR NUCLEUS

KW - ADRENALINE

KW - CORTICOSTERONE

KW - IPSAPIRONE

KW - RECEPTORS

KW - 8-OH-DPAT

KW - RESPONSES

KW - SECRETION

KW - NUCLEUS

M3 - Comment/Letter to the editor

SN - 0014-2999

VL - 197

SP - 225

EP - 228

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

INVOLVEMENT OF HYPOTHALAMIC SEROTONIN IN ACTIVATION OF THE SYMPATHOADRENOMEDULLARY SYSTEM AND HYPOTHALAMO-PITUITARY-ADRENOCORTICAL AXIS IN MALE WISTAR RATS

Abstract

Keywords

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