Abstract
It was shown recently that dietary linoleic acid could modulate β-adrenergic receptor function in guinea pig tracheal spirals (Loesberg, Folerts & Nijkamp. Prostagland Leukotr. essen. Fatty acids, in press). In the present study the relationship between β-adrenergic receptor function and oxygen radical production was examined by analyzing the effect of dietary linoleic acid (3, 6 and 12 energy%) on superoxide anion production of guinea pig alveolar macrophages and on relaxation of tracheal spirals upon β-adrenergic receptor stimulation. An additional dietary group receiving fish oil (3 energy%) in addition to 3 energy% linoleic acid was also included in this study. The zymosan-stimulated (but not the basal) superoxide anion production of the alveolar macrophages differed between the dietary groups. Highest superoxide production was found in those diets that showed the greatest deterioration of β-adrenergic receptor function. Moreover, a highly significant positive correlation was demonstrated between the amount of generated superoxide and the severity of the attenuation of the β-adrenergic receptor function in the individual animals. These data suggest that optimal dietary conditions could lead to an improved lung function possibly via modulation of alveolar macrophage radical production.
| Original language | English |
|---|---|
| Pages (from-to) | 165-171 |
| Number of pages | 7 |
| Journal | International Journal of Immunopharmacology |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 26 Jan 1989 |
Keywords
- beta adrenergic receptor
- linoleic acid
- oxygen radical
- superoxide
- animal cell
- animal experiment
- biological model
- cell culture
- cytochemistry
- diet
- guinea pig
- macrophage
- methodology
- nonhuman
- phagocytosis
- priority journal