Intestinal Organoids—Current and Future Applications

Andre Meneses; Kerstin Schneeberger; Hedwig Kruitwagen; Louis Penning; Frank van Steenbeek; Iwan Burgener; Bart Spee

doi:10.3390/vetsci3040031

Intestinal Organoids—Current and Future Applications

Andre Meneses, Kerstin Schneeberger, Hedwig Kruitwagen, Louis Penning, Frank van Steenbeek, Iwan Burgener, Bart Spee

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into three-dimensional (3D)-structures. Since organoids can be grown from different species (human, mouse, cat, dog), organs (intestine, kidney, brain, liver), and from patient-derived induced pluripotent stem cells, they create significant prospects for modelling development and diseases, for toxicology and drug discovery studies, and in the field of regenerative medicine. Here, we report on intestinal stem cells, organoid culture, organoid disease modeling, transplantation, specifically covering the current and future uses of this exciting new insight model to the field of veterinary medicine.

Original language	English
Pages (from-to)	31
Number of pages	1
Journal	Veterinary Sciences
Volume	3
Issue number	4
DOIs	https://doi.org/10.3390/vetsci3040031
Publication status	Published - 21 Oct 2016

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title = "Intestinal Organoids—Current and Future Applications",

abstract = "Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into three-dimensional (3D)-structures. Since organoids can be grown from different species (human, mouse, cat, dog), organs (intestine, kidney, brain, liver), and from patient-derived induced pluripotent stem cells, they create significant prospects for modelling development and diseases, for toxicology and drug discovery studies, and in the field of regenerative medicine. Here, we report on intestinal stem cells, organoid culture, organoid disease modeling, transplantation, specifically covering the current and future uses of this exciting new insight model to the field of veterinary medicine.",

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AU - Meneses, Andre

AU - Schneeberger, Kerstin

AU - Kruitwagen, Hedwig

AU - Penning, Louis

AU - van Steenbeek, Frank

AU - Burgener, Iwan

AU - Spee, Bart

PY - 2016/10/21

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N2 - Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into three-dimensional (3D)-structures. Since organoids can be grown from different species (human, mouse, cat, dog), organs (intestine, kidney, brain, liver), and from patient-derived induced pluripotent stem cells, they create significant prospects for modelling development and diseases, for toxicology and drug discovery studies, and in the field of regenerative medicine. Here, we report on intestinal stem cells, organoid culture, organoid disease modeling, transplantation, specifically covering the current and future uses of this exciting new insight model to the field of veterinary medicine.

AB - Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into three-dimensional (3D)-structures. Since organoids can be grown from different species (human, mouse, cat, dog), organs (intestine, kidney, brain, liver), and from patient-derived induced pluripotent stem cells, they create significant prospects for modelling development and diseases, for toxicology and drug discovery studies, and in the field of regenerative medicine. Here, we report on intestinal stem cells, organoid culture, organoid disease modeling, transplantation, specifically covering the current and future uses of this exciting new insight model to the field of veterinary medicine.

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M3 - Article

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VL - 3

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JO - Veterinary Sciences

JF - Veterinary Sciences

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ER -

Intestinal Organoids—Current and Future Applications

Abstract

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