TY - JOUR
T1 - Intestinal Organoids-Current and Future Applications
AU - Meneses, Andre M C
AU - Schneeberger, Kerstin
AU - Kruitwagen, Hedwig S
AU - Penning, Louis C
AU - van Steenbeek, Frank G
AU - Burgener, Iwan A
AU - Spee, Bart
PY - 2016
Y1 - 2016
N2 - Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into three-dimensional (3D)-structures. Since organoids can be grown from different species (human, mouse, cat, dog), organs (intestine, kidney, brain, liver), and from patient-derived induced pluripotent stem cells, they create significant prospects for modelling development and diseases, for toxicology and drug discovery studies, and in the field of regenerative medicine. Here, we report on intestinal stem cells, organoid culture, organoid disease modeling, transplantation, specifically covering the current and future uses of this exciting new insight model to the field of veterinary medicine.
AB - Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into three-dimensional (3D)-structures. Since organoids can be grown from different species (human, mouse, cat, dog), organs (intestine, kidney, brain, liver), and from patient-derived induced pluripotent stem cells, they create significant prospects for modelling development and diseases, for toxicology and drug discovery studies, and in the field of regenerative medicine. Here, we report on intestinal stem cells, organoid culture, organoid disease modeling, transplantation, specifically covering the current and future uses of this exciting new insight model to the field of veterinary medicine.
KW - Journal Article
KW - Review
U2 - 10.3390/vetsci3040031
DO - 10.3390/vetsci3040031
M3 - Review article
C2 - 29056739
SN - 2306-7381
VL - 3
JO - Veterinary Sciences
JF - Veterinary Sciences
IS - 4
ER -