Abstract
Solid evidence: Induction of the polymerization of β-tubulin dimers into microtubules by epothilones, such as patupilone, by an as yet unknown mechanism leads to the apoptosis of cancer cells. Solid-state NMR spectroscopy of patupilone bound to microtubules has now enabled the identification of atomic positions of the drug that undergo clear chemical-shift changes upon binding (see correlation spectra of free (black) and complexed patupilone (red)).
Original language | English |
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Pages (from-to) | 7504-7507 |
Number of pages | 4 |
Journal | Angewandte Chemie-International Edition |
Volume | 49 |
Issue number | 41 |
DOIs | |
Publication status | Published - 2010 |