Interaction of epothilone B (patupilone) with microtubules as detected by two-dimensional solid-state NMR spectroscopy

A. Kumar, H. Heise, M. J. J. Blommers, P. Krastel, E. Schmitt, F. Petersen, S. Jeganathan, E. -M Mandelkow, T. Carlomagno, C. Griesinger, M. Baldus

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Solid evidence: Induction of the polymerization of β-tubulin dimers into microtubules by epothilones, such as patupilone, by an as yet unknown mechanism leads to the apoptosis of cancer cells. Solid-state NMR spectroscopy of patupilone bound to microtubules has now enabled the identification of atomic positions of the drug that undergo clear chemical-shift changes upon binding (see correlation spectra of free (black) and complexed patupilone (red)).
Original languageEnglish
Pages (from-to)7504-7507
Number of pages4
JournalAngewandte Chemie-International Edition
Volume49
Issue number41
DOIs
Publication statusPublished - 2010

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