Intensive regional vaccination with a gI-deleted vaccine markedly reduces pseudorabies virus infections

J A Stegeman; M J Tielen; T G Kimman; J T Van Oirschot; W A Hunneman; F W Berndsen

doi:10.1016/0264-410x(94)90312-3

Intensive regional vaccination with a gI-deleted vaccine markedly reduces pseudorabies virus infections

J A Stegeman
, M J Tielen
, T G Kimman
, J T Van Oirschot
, W A Hunneman
, F W Berndsen

Animal Health Service in the Southern Netherlands

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The development of marker vaccines against pseudorabies virus (PRV) and companion diagnostic tests have enabled us to perform a unique field trial. In this study, the effect of intensive regional vaccination on pig-finishing herd immunity was directly measured by comparing the seroprevalence of antibodies to glycoprotein I in trial and control groups. The seroprevalence of infected finishing herds in the trial region decreased from 81% at the start of the trial to 19% after 2 years (p < 0.001). The mean seroprevalence of infected pigs in these herds diminished from 49 to 5% (p < 0.001). In the control group, representing routine PRV control, no significant change in seroprevalences was noticed.

Original language	English
Pages (from-to)	527-31
Number of pages	5
Journal	Vaccine
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/0264-410x(94)90312-3
Publication status	Published - May 1994

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Antibodies, Viral/blood
Herpesvirus 1, Suid/immunology
Pseudorabies/prevention & control
Swine
Swine Diseases/prevention & control
Vaccination
Viral Envelope Proteins/immunology
Viral Vaccines/immunology

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10.1016/0264-410x(94)90312-3

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title = "Intensive regional vaccination with a gI-deleted vaccine markedly reduces pseudorabies virus infections",

abstract = "The development of marker vaccines against pseudorabies virus (PRV) and companion diagnostic tests have enabled us to perform a unique field trial. In this study, the effect of intensive regional vaccination on pig-finishing herd immunity was directly measured by comparing the seroprevalence of antibodies to glycoprotein I in trial and control groups. The seroprevalence of infected finishing herds in the trial region decreased from 81\% at the start of the trial to 19\% after 2 years (p < 0.001). The mean seroprevalence of infected pigs in these herds diminished from 49 to 5\% (p < 0.001). In the control group, representing routine PRV control, no significant change in seroprevalences was noticed.",

keywords = "Animals, Antibodies, Viral/blood, Herpesvirus 1, Suid/immunology, Pseudorabies/prevention \& control, Swine, Swine Diseases/prevention \& control, Vaccination, Viral Envelope Proteins/immunology, Viral Vaccines/immunology",

author = "Stegeman, \{J A\} and Tielen, \{M J\} and Kimman, \{T G\} and \{Van Oirschot\}, \{J T\} and Hunneman, \{W A\} and Berndsen, \{F W\}",

year = "1994",

month = may,

doi = "10.1016/0264-410x(94)90312-3",

language = "English",

volume = "12",

pages = "527--31",

journal = "Vaccine",

issn = "0264-410X",

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TY - JOUR

T1 - Intensive regional vaccination with a gI-deleted vaccine markedly reduces pseudorabies virus infections

AU - Stegeman, J A

AU - Tielen, M J

AU - Kimman, T G

AU - Van Oirschot, J T

AU - Hunneman, W A

AU - Berndsen, F W

PY - 1994/5

Y1 - 1994/5

N2 - The development of marker vaccines against pseudorabies virus (PRV) and companion diagnostic tests have enabled us to perform a unique field trial. In this study, the effect of intensive regional vaccination on pig-finishing herd immunity was directly measured by comparing the seroprevalence of antibodies to glycoprotein I in trial and control groups. The seroprevalence of infected finishing herds in the trial region decreased from 81% at the start of the trial to 19% after 2 years (p < 0.001). The mean seroprevalence of infected pigs in these herds diminished from 49 to 5% (p < 0.001). In the control group, representing routine PRV control, no significant change in seroprevalences was noticed.

AB - The development of marker vaccines against pseudorabies virus (PRV) and companion diagnostic tests have enabled us to perform a unique field trial. In this study, the effect of intensive regional vaccination on pig-finishing herd immunity was directly measured by comparing the seroprevalence of antibodies to glycoprotein I in trial and control groups. The seroprevalence of infected finishing herds in the trial region decreased from 81% at the start of the trial to 19% after 2 years (p < 0.001). The mean seroprevalence of infected pigs in these herds diminished from 49 to 5% (p < 0.001). In the control group, representing routine PRV control, no significant change in seroprevalences was noticed.

KW - Animals

KW - Antibodies, Viral/blood

KW - Herpesvirus 1, Suid/immunology

KW - Pseudorabies/prevention & control

KW - Swine

KW - Swine Diseases/prevention & control

KW - Vaccination

KW - Viral Envelope Proteins/immunology

KW - Viral Vaccines/immunology

U2 - 10.1016/0264-410x(94)90312-3

DO - 10.1016/0264-410x(94)90312-3

M3 - Article

C2 - 8036827

SN - 0264-410X

VL - 12

SP - 527

EP - 531

JO - Vaccine

JF - Vaccine

IS - 6

ER -

Intensive regional vaccination with a gI-deleted vaccine markedly reduces pseudorabies virus infections

Abstract

UN SDGs

Keywords

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