Intensive regional vaccination with a gI-deleted vaccine markedly reduces pseudorabies virus infections

J A Stegeman; M J Tielen; T G Kimman; J T Van Oirschot; W A Hunneman; F W Berndsen

doi:10.1016/0264-410x(94)90312-3

Intensive regional vaccination with a gI-deleted vaccine markedly reduces pseudorabies virus infections

J A Stegeman, M J Tielen, T G Kimman, J T Van Oirschot, W A Hunneman, F W Berndsen

Animal Health Service in the Southern Netherlands

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The development of marker vaccines against pseudorabies virus (PRV) and companion diagnostic tests have enabled us to perform a unique field trial. In this study, the effect of intensive regional vaccination on pig-finishing herd immunity was directly measured by comparing the seroprevalence of antibodies to glycoprotein I in trial and control groups. The seroprevalence of infected finishing herds in the trial region decreased from 81% at the start of the trial to 19% after 2 years (p < 0.001). The mean seroprevalence of infected pigs in these herds diminished from 49 to 5% (p < 0.001). In the control group, representing routine PRV control, no significant change in seroprevalences was noticed.

Original language	English
Pages (from-to)	527-31
Number of pages	5
Journal	Vaccine
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/0264-410x(94)90312-3
Publication status	Published - May 1994

Keywords

Animals
Antibodies, Viral/blood
Herpesvirus 1, Suid/immunology
Pseudorabies/prevention & control
Swine
Swine Diseases/prevention & control
Vaccination
Viral Envelope Proteins/immunology
Viral Vaccines/immunology

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10.1016/0264-410x(94)90312-3

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title = "Intensive regional vaccination with a gI-deleted vaccine markedly reduces pseudorabies virus infections",

abstract = "The development of marker vaccines against pseudorabies virus (PRV) and companion diagnostic tests have enabled us to perform a unique field trial. In this study, the effect of intensive regional vaccination on pig-finishing herd immunity was directly measured by comparing the seroprevalence of antibodies to glycoprotein I in trial and control groups. The seroprevalence of infected finishing herds in the trial region decreased from 81% at the start of the trial to 19% after 2 years (p < 0.001). The mean seroprevalence of infected pigs in these herds diminished from 49 to 5% (p < 0.001). In the control group, representing routine PRV control, no significant change in seroprevalences was noticed.",

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author = "Stegeman, {J A} and Tielen, {M J} and Kimman, {T G} and {Van Oirschot}, {J T} and Hunneman, {W A} and Berndsen, {F W}",

year = "1994",

month = may,

doi = "10.1016/0264-410x(94)90312-3",

language = "English",

volume = "12",

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journal = "Vaccine",

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T1 - Intensive regional vaccination with a gI-deleted vaccine markedly reduces pseudorabies virus infections

AU - Stegeman, J A

AU - Tielen, M J

AU - Kimman, T G

AU - Van Oirschot, J T

AU - Hunneman, W A

AU - Berndsen, F W

PY - 1994/5

Y1 - 1994/5

N2 - The development of marker vaccines against pseudorabies virus (PRV) and companion diagnostic tests have enabled us to perform a unique field trial. In this study, the effect of intensive regional vaccination on pig-finishing herd immunity was directly measured by comparing the seroprevalence of antibodies to glycoprotein I in trial and control groups. The seroprevalence of infected finishing herds in the trial region decreased from 81% at the start of the trial to 19% after 2 years (p < 0.001). The mean seroprevalence of infected pigs in these herds diminished from 49 to 5% (p < 0.001). In the control group, representing routine PRV control, no significant change in seroprevalences was noticed.

AB - The development of marker vaccines against pseudorabies virus (PRV) and companion diagnostic tests have enabled us to perform a unique field trial. In this study, the effect of intensive regional vaccination on pig-finishing herd immunity was directly measured by comparing the seroprevalence of antibodies to glycoprotein I in trial and control groups. The seroprevalence of infected finishing herds in the trial region decreased from 81% at the start of the trial to 19% after 2 years (p < 0.001). The mean seroprevalence of infected pigs in these herds diminished from 49 to 5% (p < 0.001). In the control group, representing routine PRV control, no significant change in seroprevalences was noticed.

KW - Animals

KW - Antibodies, Viral/blood

KW - Herpesvirus 1, Suid/immunology

KW - Pseudorabies/prevention & control

KW - Swine

KW - Swine Diseases/prevention & control

KW - Vaccination

KW - Viral Envelope Proteins/immunology

KW - Viral Vaccines/immunology

U2 - 10.1016/0264-410x(94)90312-3

DO - 10.1016/0264-410x(94)90312-3

M3 - Article

C2 - 8036827

SN - 0264-410X

VL - 12

SP - 527

EP - 531

JO - Vaccine

JF - Vaccine

IS - 6

ER -

Intensive regional vaccination with a gI-deleted vaccine markedly reduces pseudorabies virus infections

Abstract

Keywords

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