Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors

H Schelleman; O H Klungel; C M van Duijn; J C M Witteman; A Hofman; A de Boer; B H Ch Stricker

doi:10.1111/j.1365-2125.2004.02332.x

Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors

H Schelleman, O H Klungel, C M van Duijn, J C M Witteman, A Hofman, A de Boer, B H Ch Stricker

Dep Farmaceutische wetenschappen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

AIMS: We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug.

METHODS: This was a cohort study among 239 subjects who started ACE inhibitor therapy. A Cox proportional hazard model was used to calculate relative risk (RR).

RESULTS: During follow-up there was no significant difference between subjects with the DD, ID or II genotype (DD vs II; RR = 1.17, 95%CI: 0.78, 1.77 and ID vs II; RR = 1.06, 95%CI: 0.73, 1.55) in adherence.

CONCLUSIONS: The I/D polymorphism of the ACE gene does not influence the adherence to ACE inhibitors.

Original language	English
Pages (from-to)	483-485
Number of pages	3
Journal	British Journal of Clinical Pharmacology
Volume	59
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2125.2004.02332.x
Publication status	Published - Apr 2005

Keywords

Aged
Analysis of Variance
Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Agents
Cohort Studies
DNA Transposable Elements
Gene Deletion
Genotype
Humans
Hypertension
Middle Aged
Patient Compliance
Polymerase Chain Reaction
Polymorphism, Genetic
Prospective Studies
Risk Assessment

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Boer 04 SchellemanInsertiondeletionpolymorphismoftheACE
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@article{6531ce465c7f443eb065a6e24ff3705a,

title = "Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors",

abstract = "AIMS: We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug.METHODS: This was a cohort study among 239 subjects who started ACE inhibitor therapy. A Cox proportional hazard model was used to calculate relative risk (RR).RESULTS: During follow-up there was no significant difference between subjects with the DD, ID or II genotype (DD vs II; RR = 1.17, 95%CI: 0.78, 1.77 and ID vs II; RR = 1.06, 95%CI: 0.73, 1.55) in adherence.CONCLUSIONS: The I/D polymorphism of the ACE gene does not influence the adherence to ACE inhibitors.",

keywords = "Aged, Analysis of Variance, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Cohort Studies, DNA Transposable Elements, Gene Deletion, Genotype, Humans, Hypertension, Middle Aged, Patient Compliance, Polymerase Chain Reaction, Polymorphism, Genetic, Prospective Studies, Risk Assessment",

author = "H Schelleman and Klungel, {O H} and {van Duijn}, {C M} and Witteman, {J C M} and A Hofman and {de Boer}, A and Stricker, {B H Ch}",

year = "2005",

month = apr,

doi = "10.1111/j.1365-2125.2004.02332.x",

language = "English",

volume = "59",

pages = "483--485",

journal = "British Journal of Clinical Pharmacology",

issn = "0306-5251",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "4",

}

TY - JOUR

T1 - Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors

AU - Schelleman, H

AU - Klungel, O H

AU - van Duijn, C M

AU - Witteman, J C M

AU - Hofman, A

AU - de Boer, A

AU - Stricker, B H Ch

PY - 2005/4

Y1 - 2005/4

N2 - AIMS: We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug.METHODS: This was a cohort study among 239 subjects who started ACE inhibitor therapy. A Cox proportional hazard model was used to calculate relative risk (RR).RESULTS: During follow-up there was no significant difference between subjects with the DD, ID or II genotype (DD vs II; RR = 1.17, 95%CI: 0.78, 1.77 and ID vs II; RR = 1.06, 95%CI: 0.73, 1.55) in adherence.CONCLUSIONS: The I/D polymorphism of the ACE gene does not influence the adherence to ACE inhibitors.

AB - AIMS: We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug.METHODS: This was a cohort study among 239 subjects who started ACE inhibitor therapy. A Cox proportional hazard model was used to calculate relative risk (RR).RESULTS: During follow-up there was no significant difference between subjects with the DD, ID or II genotype (DD vs II; RR = 1.17, 95%CI: 0.78, 1.77 and ID vs II; RR = 1.06, 95%CI: 0.73, 1.55) in adherence.CONCLUSIONS: The I/D polymorphism of the ACE gene does not influence the adherence to ACE inhibitors.

KW - Aged

KW - Analysis of Variance

KW - Angiotensin-Converting Enzyme Inhibitors

KW - Antihypertensive Agents

KW - Cohort Studies

KW - DNA Transposable Elements

KW - Gene Deletion

KW - Genotype

KW - Humans

KW - Hypertension

KW - Middle Aged

KW - Patient Compliance

KW - Polymerase Chain Reaction

KW - Polymorphism, Genetic

KW - Prospective Studies

KW - Risk Assessment

U2 - 10.1111/j.1365-2125.2004.02332.x

DO - 10.1111/j.1365-2125.2004.02332.x

M3 - Article

C2 - 15801945

SN - 0306-5251

VL - 59

SP - 483

EP - 485

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 4

ER -

Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors

Abstract

Keywords

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