Inhibition of H1 and H5 Influenza A Virus Entry by Diverse Macrocyclic Peptides Targeting the Hemagglutinin Stem Region: ACS Chemical Biology

Keyphrases

• Influenza Virus 100%
• Virus Entry 100%
• Chemical Biology 100%
• Peptide Targeting 100%
• Stem Region 100%
• Hemagglutinin Stem 100%
• Macrocyclic Peptides 100%
• New Treatment Options 25%
• Therapeutic Potential 25%
• Virus-cell Fusion 25%
• Cytotoxicity 25%
• Binding Site 25%
• Peptide Library 25%
• Influenza-like Illness 25%
• Hemagglutinin 25%
• Functional Analysis 25%
• Antibody Binding 25%
• Hydrogen-deuterium Exchange Mass Spectrometry 25%
• High-throughput Screening 25%
• Ultrahigh-throughput Screening 25%
• Epitope Mapping 25%
• Sequence Diversity 25%
• Immunodominance 25%
• Prefusion Conformation 25%
• Head Region 25%
• Pandemic Risk 25%
• Druggable Site 25%
• In Vitro Display 25%
• Viral Fusion Inhibitor 25%
• Nanomolar Concentrations 25%
• Escape Variants 25%

Immunology and Microbiology

• Hemagglutinin 100%
• Influenzavirus A 100%
• Viral Entry 100%
• Viral Disease 33%
• Binding Antibody 33%
• Immunodominance 33%
• Hydrogen/Deuterium Exchange Mass Spectrometry 33%
• Conformation 33%
• Cytotoxicity 33%
• High Throughput Screening 33%
• Peptide Library 33%
• Binding Site 33%
• Cell Fusion 33%
• Epitope Mapping 33%
• Immunology 33%

Biochemistry, Genetics and Molecular Biology

• Hemagglutinin 100%
• Influenza A Virus 100%
• Virus Entry 100%
• Conformation 33%
• Cell Fusion 33%
• Hydrogen/Deuterium Exchange Mass Spectrometry 33%
• Binding Site 33%
• Peptide Library 33%
• High Throughput Screening 33%
• Epitope Mapping 33%
• Cytotoxicity 33%