Influence of transgenic corticotropin-releasing factor (CRF) over-expression on social recognition memory in mice

Maki Kasahara; Lucianne Groenink; Martien J H Kas; Elisabeth Y Bijlsma; Berend Olivier; Zoltán Sarnyai

doi:10.1016/j.bbr.2010.12.029

Influence of transgenic corticotropin-releasing factor (CRF) over-expression on social recognition memory in mice

Maki Kasahara, Lucianne Groenink, Martien J H Kas, Elisabeth Y Bijlsma, Berend Olivier, Zoltán Sarnyai

Pharmacology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We examined juvenile social recognition and discrimination in mice with early post-natal onset, transgenic CRF over-expression (CRF-OE) and in their wild-type littermates (WT). CRF-OE mice showed enhanced social investigation during the first encounter, normal short-term and facilitated long-term social recognition memory, compared to WT. These results suggest that chronically elevated brain CRF tone may contribute in better remembering ethologically relevant and emotionally salient stimuli, such as social interaction.

Original language	English
Pages (from-to)	357-362
Number of pages	6
Journal	Behavioural Brain Research
Volume	218
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2010.12.029
Publication status	Published - 15 Apr 2011

Bibliographical note

Keywords

Analysis of Variance
Animals
Corticotropin-Releasing Hormone
Mice
Mice, Transgenic
Recognition (Psychology)
Social Behavior

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title = "Influence of transgenic corticotropin-releasing factor (CRF) over-expression on social recognition memory in mice",

abstract = "We examined juvenile social recognition and discrimination in mice with early post-natal onset, transgenic CRF over-expression (CRF-OE) and in their wild-type littermates (WT). CRF-OE mice showed enhanced social investigation during the first encounter, normal short-term and facilitated long-term social recognition memory, compared to WT. These results suggest that chronically elevated brain CRF tone may contribute in better remembering ethologically relevant and emotionally salient stimuli, such as social interaction.",

keywords = "Analysis of Variance, Animals, Corticotropin-Releasing Hormone, Mice, Mice, Transgenic, Recognition (Psychology), Social Behavior",

author = "Maki Kasahara and Lucianne Groenink and Kas, \{Martien J H\} and Bijlsma, \{Elisabeth Y\} and Berend Olivier and Zolt{\'a}n Sarnyai",

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AU - Kasahara, Maki

AU - Groenink, Lucianne

AU - Kas, Martien J H

AU - Bijlsma, Elisabeth Y

AU - Olivier, Berend

AU - Sarnyai, Zoltán

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KW - Analysis of Variance

KW - Animals

KW - Corticotropin-Releasing Hormone

KW - Mice

KW - Mice, Transgenic

KW - Recognition (Psychology)

KW - Social Behavior

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DO - 10.1016/j.bbr.2010.12.029

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EP - 362

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 2

ER -

Influence of transgenic corticotropin-releasing factor (CRF) over-expression on social recognition memory in mice

Abstract

Bibliographical note

Keywords

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