Influence of mode of delivery on cytokine expression in cord blood

Bindu Nandanan; Mei Chien Chua; Wen Chin Chiang; Anne Goh; Dinesh Kumar; Leon Knippels; Johan Garssen; Elena Sandalova

doi:10.1016/j.humimm.2019.03.018

Influence of mode of delivery on cytokine expression in cord blood

Bindu Nandanan, Mei Chien Chua, Wen Chin Chiang, Anne Goh, Dinesh Kumar, Leon Knippels, Johan Garssen, Elena Sandalova^*

^*Corresponding author for this work

Danone Nutricia Research, Singapore.
Department of Paediatrics, Allergy Service, KK Women's and Children's Hospital, Singapore.
Danone Nutricia Research, Singapore; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, the Netherlands. Electronic address: [email protected].

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The mode of delivery is a known risk factor for immune-related disorders. Normal term vaginal delivery is an inflammatory process and several cytokines are suggested to be involved. The purpose of the study was to evaluate differences in cord blood cytokine expression between modes of delivery in term-born children. Cord blood was collected from 49 elective Caesarean section (C-section) cases and from 49 normal vaginal term deliveries. Plasma was tested for 17 cytokines with Bio-Plex®-200-system. Mann-Whitney test was used for comparing the groups with Bonferroni correction for multiple testing. Four cytokines showed significant differences between the modes of delivery. Interleukin-6, Interleukin-8 showed a significantly higher expression in the vaginal delivery group, while Tumor-Necrosis Factor-a, Granulocyte-Colony Stimulating Factor showed a significantly higher level of expression in the C-section cord blood. Our study shows that there is differential expression of pro-inflammatory cytokines in elective C-section compared with normal term vaginal delivery.

Original language	English
Pages (from-to)	533-536
Number of pages	4
Journal	Human Immunology
Volume	80
Issue number	7
DOIs	https://doi.org/10.1016/j.humimm.2019.03.018
Publication status	Published - Jul 2019

Keywords

000474324200024
Cesarean Section
Cohort Studies
Delivery, Obstetric
Female
Fetal Blood/immunology
Granulocyte Colony-Stimulating Factor/blood
Humans
Infant, Newborn
Interleukin-6/blood
Interleukin-8/blood
Male
Pregnancy
Tumor Necrosis Factor-alpha/blood
Young Adult

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10.1016/j.humimm.2019.03.018

1-s2.0-S0198885919301740-mainFinal published version, 538 KBLicence: Taverne

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title = "Influence of mode of delivery on cytokine expression in cord blood",

abstract = "The mode of delivery is a known risk factor for immune-related disorders. Normal term vaginal delivery is an inflammatory process and several cytokines are suggested to be involved. The purpose of the study was to evaluate differences in cord blood cytokine expression between modes of delivery in term-born children. Cord blood was collected from 49 elective Caesarean section (C-section) cases and from 49 normal vaginal term deliveries. Plasma was tested for 17 cytokines with Bio-Plex{\textregistered}-200-system. Mann-Whitney test was used for comparing the groups with Bonferroni correction for multiple testing. Four cytokines showed significant differences between the modes of delivery. Interleukin-6, Interleukin-8 showed a significantly higher expression in the vaginal delivery group, while Tumor-Necrosis Factor-a, Granulocyte-Colony Stimulating Factor showed a significantly higher level of expression in the C-section cord blood. Our study shows that there is differential expression of pro-inflammatory cytokines in elective C-section compared with normal term vaginal delivery.",

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author = "Bindu Nandanan and Chua, \{Mei Chien\} and Chiang, \{Wen Chin\} and Anne Goh and Dinesh Kumar and Leon Knippels and Johan Garssen and Elena Sandalova",

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AU - Nandanan, Bindu

AU - Chua, Mei Chien

AU - Chiang, Wen Chin

AU - Goh, Anne

AU - Kumar, Dinesh

AU - Knippels, Leon

AU - Garssen, Johan

AU - Sandalova, Elena

PY - 2019/7

Y1 - 2019/7

N2 - The mode of delivery is a known risk factor for immune-related disorders. Normal term vaginal delivery is an inflammatory process and several cytokines are suggested to be involved. The purpose of the study was to evaluate differences in cord blood cytokine expression between modes of delivery in term-born children. Cord blood was collected from 49 elective Caesarean section (C-section) cases and from 49 normal vaginal term deliveries. Plasma was tested for 17 cytokines with Bio-Plex®-200-system. Mann-Whitney test was used for comparing the groups with Bonferroni correction for multiple testing. Four cytokines showed significant differences between the modes of delivery. Interleukin-6, Interleukin-8 showed a significantly higher expression in the vaginal delivery group, while Tumor-Necrosis Factor-a, Granulocyte-Colony Stimulating Factor showed a significantly higher level of expression in the C-section cord blood. Our study shows that there is differential expression of pro-inflammatory cytokines in elective C-section compared with normal term vaginal delivery.

AB - The mode of delivery is a known risk factor for immune-related disorders. Normal term vaginal delivery is an inflammatory process and several cytokines are suggested to be involved. The purpose of the study was to evaluate differences in cord blood cytokine expression between modes of delivery in term-born children. Cord blood was collected from 49 elective Caesarean section (C-section) cases and from 49 normal vaginal term deliveries. Plasma was tested for 17 cytokines with Bio-Plex®-200-system. Mann-Whitney test was used for comparing the groups with Bonferroni correction for multiple testing. Four cytokines showed significant differences between the modes of delivery. Interleukin-6, Interleukin-8 showed a significantly higher expression in the vaginal delivery group, while Tumor-Necrosis Factor-a, Granulocyte-Colony Stimulating Factor showed a significantly higher level of expression in the C-section cord blood. Our study shows that there is differential expression of pro-inflammatory cytokines in elective C-section compared with normal term vaginal delivery.

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KW - Cohort Studies

KW - Delivery, Obstetric

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KW - Fetal Blood/immunology

KW - Granulocyte Colony-Stimulating Factor/blood

KW - Humans

KW - Infant, Newborn

KW - Interleukin-6/blood

KW - Interleukin-8/blood

KW - Male

KW - Pregnancy

KW - Tumor Necrosis Factor-alpha/blood

KW - Young Adult

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DO - 10.1016/j.humimm.2019.03.018

M3 - Article

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VL - 80

SP - 533

EP - 536

JO - Human Immunology

JF - Human Immunology

IS - 7

ER -

Influence of mode of delivery on cytokine expression in cord blood

Abstract

Keywords

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