TY - JOUR
T1 - Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition
AU - Solans, Marta
AU - Benavente, Yolanda
AU - Saez, Marc
AU - Agudo, Antonio
AU - Jakszyn, Paula
AU - Naudin, Sabine
AU - Hosnijeh, Fatemeh Saberi
AU - Gunter, Marc
AU - Huybrechts, Inge
AU - Ferrari, Pietro
AU - Besson, Caroline
AU - Mahamat-Saleh, Yahya
AU - Boutron-Ruault, Marie Christine
AU - Kühn, Tilman
AU - Kaaks, Rudolf
AU - Boeing, Heiner
AU - Lasheras, Cristina
AU - Sánchez, Maria Jose
AU - Amiano, Pilar
AU - Chirlaque, María Dolores
AU - Ardanaz, Eva
AU - Schmidt, Julie A.
AU - Vineis, Paolo
AU - Riboli, Elio
AU - Trichopoulou, Antonia
AU - Karakatsani, Anna
AU - Valanou, Elisavet
AU - Masala, Giovanna
AU - Agnoli, Claudia
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Mattiello, Amalia
AU - Skeie, Guri
AU - Weiderpass, Elisabete
AU - Jerkeman, Mats
AU - Dias, Joana Alves
AU - Späth, Florentin
AU - Nilsson, Lena Maria
AU - Dahm, Christina C.
AU - Overvad, Kim
AU - Petersen, Kristina Elin Nielsen
AU - Tjønneland, Anne
AU - de Sanjose, Silvia
AU - Vermeulen, Roel
AU - Nieters, Alexandra
AU - Casabonne, Delphine
PY - 2019/3/22
Y1 - 2019/3/22
N2 - Background Chronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation. Objective We assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia cancers and noncardia cancers. Design A total of 476,160 subjects (30% men, 70% women) from the European Investigation into Cancer and Nutrition (EPIC) study were followed for 14 y, during which 913 incident cases of gastric carcinoma were identified, including 236 located in the cardia, 341 in the distal part of the stomach (noncardia), and 336 with overlapping or unknown tumor site. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated with the use of 28 dietary components and their corresponding inflammatory scores. The association between the ISD and gastric cancer risk was estimated by HRs and 95% CIs calculated by multivariate Cox regression models adjusted for confounders. Results The inflammatory potential of the diet was associated with an increased risk of gastric cancer. The HR (95% CI) for each increase in 1 SD of the ISD were 1.25 (1.12, 1.39) for all gastric cancers, 1.30 (1.06, 1.59) for cardia cancers, and 1.07 (0.89, 1.28) for noncardia cancers. The corresponding values for the highest compared with the lowest quartiles of the ISD were 1.66 (1.26, 2.20), 1.94 (1.14, 3.30), and 1.07 (0.70, 1.70), respectively. Conclusions Our results suggest that low-grade chronic inflammation induced by the diet may be associated with gastric cancer risk. This pattern seems to be more consistent for gastric carcinomas located in the cardia than for those located in the distal stomach. This study is listed on the ISRCTN registry as ISRCTN12136108.
AB - Background Chronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation. Objective We assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia cancers and noncardia cancers. Design A total of 476,160 subjects (30% men, 70% women) from the European Investigation into Cancer and Nutrition (EPIC) study were followed for 14 y, during which 913 incident cases of gastric carcinoma were identified, including 236 located in the cardia, 341 in the distal part of the stomach (noncardia), and 336 with overlapping or unknown tumor site. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated with the use of 28 dietary components and their corresponding inflammatory scores. The association between the ISD and gastric cancer risk was estimated by HRs and 95% CIs calculated by multivariate Cox regression models adjusted for confounders. Results The inflammatory potential of the diet was associated with an increased risk of gastric cancer. The HR (95% CI) for each increase in 1 SD of the ISD were 1.25 (1.12, 1.39) for all gastric cancers, 1.30 (1.06, 1.59) for cardia cancers, and 1.07 (0.89, 1.28) for noncardia cancers. The corresponding values for the highest compared with the lowest quartiles of the ISD were 1.66 (1.26, 2.20), 1.94 (1.14, 3.30), and 1.07 (0.70, 1.70), respectively. Conclusions Our results suggest that low-grade chronic inflammation induced by the diet may be associated with gastric cancer risk. This pattern seems to be more consistent for gastric carcinomas located in the cardia than for those located in the distal stomach. This study is listed on the ISRCTN registry as ISRCTN12136108.
KW - Chronic inflammation
KW - Inflammatory score of the diet
KW - Lymphoma
KW - Nutrition
KW - Prospective studies
U2 - 10.1007/s00394-019-01947-0
DO - 10.1007/s00394-019-01947-0
M3 - Article
SN - 1436-6207
VL - 59
SP - 813
EP - 823
JO - European Journal of Nutrition
JF - European Journal of Nutrition
ER -