Increased bone morphogenetic protein 7 signalling in the kidneys of dogs affected with a congenital portosystemic shunt

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    Dogs with a congenital portosystemic shunt (CPSS) often have enlarged and hyper-filtrating kidneys. Although expression of different growth factors has been well-described in the livers of dogs affected with a CPSS, their expression in the kidneys has yet to be determined. Bone morphogenetic protein 7 (BMP-7), hepatocyte growth factor (HGF) and transforming growth factor (TGF)-β have been implicated in renal development (BMP-7, HGF) or the onset of renal fibrosis (TGF-β). Moreover, BMP-7 and HGF have protective properties in renal fibrosis. In this study, the expression and activity of BMP-7 were investigated in renal biopsies obtained from 13 dogs affected with a CPSS and compared to similar samples from age-matched healthy control dogs. Both quantitative reverse-transcriptase PCR and Western blotting showed up-regulated BMP-7 signalling in kidneys of CPPS-affected dogs. These research findings may help to explain the renal pathology/dysfunction in dogs affected with a CPSS.

    Original languageEnglish
    Pages (from-to)226-228
    Number of pages3
    JournalVeterinary Journal
    Volume204
    Issue number2
    DOIs
    Publication statusPublished - 2015

    Bibliographical note

    Copyright © 2015 Elsevier Ltd. All rights reserved.

    Fingerprint

    Dive into the research topics of 'Increased bone morphogenetic protein 7 signalling in the kidneys of dogs affected with a congenital portosystemic shunt'. Together they form a unique fingerprint.

    Cite this