In vivo and ex vivo inflammatory responses of the esophageal mucosa to food challenge in adults with eosinophilic esophagitis

Maria L Haasnoot; Mirelle T A Kleuskens; Alejandro Lopez-Rincon; Mara A P Diks; Ingrid Terreehorst; Jaap H Akkerdaas; Ronald van Ree; Marleen T J van Ampting; Johan Garssen; Frank A Redegeld; Betty C A M van Esch; Albert J Bredenoord

doi:10.1111/all.15694

In vivo and ex vivo inflammatory responses of the esophageal mucosa to food challenge in adults with eosinophilic esophagitis

Maria L Haasnoot, Mirelle T A Kleuskens, Alejandro Lopez-Rincon, Mara A P Diks, Ingrid Terreehorst, Jaap H Akkerdaas, Ronald van Ree, Marleen T J van Ampting, Johan Garssen, Frank A Redegeld, Betty C A M van Esch, Albert J Bredenoord

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Original language	English
Pages (from-to)	2044-2047
Number of pages	4
Journal	Allergy
Volume	78
Issue number	7
Early online date	3 Mar 2023
DOIs	https://doi.org/10.1111/all.15694
Publication status	Published - Jul 2023

Bibliographical note

Funding Information:
This research is funded within the Partnership between NWO domain Applied and Engineered Sciences and Danone Nutricia Research and with additional financial support from Topsector Agri and Food, project number 16495 with the acronym LOIRE. AJB is supported by Vidi grant 91718300 from the Netherlands Organization for Scientific Research NWO.

Funding Information:
AJB received research funding from Norgine, Thelial, SST and received speaker and/or consulting fees from Laborie, Arena, EsoCap, Medtronic, Dr. Falk Pharma, Calypso Biotech, Alimentiv, Sanofi, Reckett, Regeneron and AstraZeneca (all unrelated to this work). RvR received consultancy fees from HAL Allergy, Citeq, Angany, Reacta Healthcare, Mission MightyMe and AB Enzymes, speaker fees from HAL Allergy, ThermoFisher Scientific and ALK, and has stock option of Angany (all unrelated to this work). MTJVA is employed by Danone Nutricia Research. JG and BCAMVE are partly employed by Danone Nutricia Research. All other authors report no conflict of interest.

Funding Information:
AJB received research funding from Norgine, Thelial, SST and received speaker and/or consulting fees from Laborie, Arena, EsoCap, Medtronic, Dr. Falk Pharma, Calypso Biotech, Alimentiv, Sanofi, Reckett, Regeneron and AstraZeneca (all unrelated to this work). RvR received consultancy fees from HAL Allergy, Citeq, Angany, Reacta Healthcare, Mission MightyMe and AB Enzymes, speaker fees from HAL Allergy, ThermoFisher Scientific and ALK, and has stock option of Angany (all unrelated to this work). MTJVA is employed by Danone Nutricia Research. JG and BCAMVE are partly employed by Danone Nutricia Research. All other authors report no conflict of interest. This research is funded within the Partnership between NWO domain Applied and Engineered Sciences and Danone Nutricia Research and with additional financial support from Topsector Agri and Food, project number 16495 with the acronym LOIRE. AJB is supported by Vidi grant 91718300 from the Netherlands Organization for Scientific Research NWO.

Funding

This research is funded within the Partnership between NWO domain Applied and Engineered Sciences and Danone Nutricia Research and with additional financial support from Topsector Agri and Food, project number 16495 with the acronym LOIRE. AJB is supported by Vidi grant 91718300 from the Netherlands Organization for Scientific Research NWO. AJB received research funding from Norgine, Thelial, SST and received speaker and/or consulting fees from Laborie, Arena, EsoCap, Medtronic, Dr. Falk Pharma, Calypso Biotech, Alimentiv, Sanofi, Reckett, Regeneron and AstraZeneca (all unrelated to this work). RvR received consultancy fees from HAL Allergy, Citeq, Angany, Reacta Healthcare, Mission MightyMe and AB Enzymes, speaker fees from HAL Allergy, ThermoFisher Scientific and ALK, and has stock option of Angany (all unrelated to this work). MTJVA is employed by Danone Nutricia Research. JG and BCAMVE are partly employed by Danone Nutricia Research. All other authors report no conflict of interest. AJB received research funding from Norgine, Thelial, SST and received speaker and/or consulting fees from Laborie, Arena, EsoCap, Medtronic, Dr. Falk Pharma, Calypso Biotech, Alimentiv, Sanofi, Reckett, Regeneron and AstraZeneca (all unrelated to this work). RvR received consultancy fees from HAL Allergy, Citeq, Angany, Reacta Healthcare, Mission MightyMe and AB Enzymes, speaker fees from HAL Allergy, ThermoFisher Scientific and ALK, and has stock option of Angany (all unrelated to this work). MTJVA is employed by Danone Nutricia Research. JG and BCAMVE are partly employed by Danone Nutricia Research. All other authors report no conflict of interest. This research is funded within the Partnership between NWO domain Applied and Engineered Sciences and Danone Nutricia Research and with additional financial support from Topsector Agri and Food, project number 16495 with the acronym LOIRE. AJB is supported by Vidi grant 91718300 from the Netherlands Organization for Scientific Research NWO.

Funders	Funder number
NWO domain Applied and Engineered Sciences and Danone Nutricia Research
Topsector Agri and Food	16495, 91718300
AstraZeneca
Danone Nutricia Research
Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Keywords

Adult
Enteritis
Eosinophilic Esophagitis/diagnosis
Esophageal Mucosa
Food/adverse effects
Humans

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10.1111/all.15694Licence: CC BY

Allergy - 2023 - Haasnoot - In vivo and ex vivo inflammatory responses of the esophageal mucosa to food challenge in adultsFinal published version, 751 KBLicence: CC BY

Cite this

Haasnoot, M. L., Kleuskens, M. T. A., Lopez-Rincon, A., Diks, M. A. P., Terreehorst, I., Akkerdaas, J. H., van Ree, R., van Ampting, M. T. J., Garssen, J., Redegeld, F. A., van Esch, B. C. A. M., & Bredenoord, A. J. (2023). In vivo and ex vivo inflammatory responses of the esophageal mucosa to food challenge in adults with eosinophilic esophagitis. Allergy, 78(7), 2044-2047. https://doi.org/10.1111/all.15694

@article{50ee3dbdd6654bcf9881e79f61789a9e,

title = "In vivo and ex vivo inflammatory responses of the esophageal mucosa to food challenge in adults with eosinophilic esophagitis",

keywords = "Adult, Enteritis, Eosinophilic Esophagitis/diagnosis, Esophageal Mucosa, Food/adverse effects, Humans",

author = "Haasnoot, {Maria L} and Kleuskens, {Mirelle T A} and Alejandro Lopez-Rincon and Diks, {Mara A P} and Ingrid Terreehorst and Akkerdaas, {Jaap H} and {van Ree}, Ronald and {van Ampting}, {Marleen T J} and Johan Garssen and Redegeld, {Frank A} and {van Esch}, {Betty C A M} and Bredenoord, {Albert J}",

note = "Funding Information: This research is funded within the Partnership between NWO domain Applied and Engineered Sciences and Danone Nutricia Research and with additional financial support from Topsector Agri and Food, project number 16495 with the acronym LOIRE. AJB is supported by Vidi grant 91718300 from the Netherlands Organization for Scientific Research NWO. Funding Information: AJB received research funding from Norgine, Thelial, SST and received speaker and/or consulting fees from Laborie, Arena, EsoCap, Medtronic, Dr. Falk Pharma, Calypso Biotech, Alimentiv, Sanofi, Reckett, Regeneron and AstraZeneca (all unrelated to this work). RvR received consultancy fees from HAL Allergy, Citeq, Angany, Reacta Healthcare, Mission MightyMe and AB Enzymes, speaker fees from HAL Allergy, ThermoFisher Scientific and ALK, and has stock option of Angany (all unrelated to this work). MTJVA is employed by Danone Nutricia Research. JG and BCAMVE are partly employed by Danone Nutricia Research. All other authors report no conflict of interest. Funding Information: AJB received research funding from Norgine, Thelial, SST and received speaker and/or consulting fees from Laborie, Arena, EsoCap, Medtronic, Dr. Falk Pharma, Calypso Biotech, Alimentiv, Sanofi, Reckett, Regeneron and AstraZeneca (all unrelated to this work). RvR received consultancy fees from HAL Allergy, Citeq, Angany, Reacta Healthcare, Mission MightyMe and AB Enzymes, speaker fees from HAL Allergy, ThermoFisher Scientific and ALK, and has stock option of Angany (all unrelated to this work). MTJVA is employed by Danone Nutricia Research. JG and BCAMVE are partly employed by Danone Nutricia Research. All other authors report no conflict of interest. This research is funded within the Partnership between NWO domain Applied and Engineered Sciences and Danone Nutricia Research and with additional financial support from Topsector Agri and Food, project number 16495 with the acronym LOIRE. AJB is supported by Vidi grant 91718300 from the Netherlands Organization for Scientific Research NWO.",

year = "2023",

month = jul,

doi = "10.1111/all.15694",

language = "English",

volume = "78",

pages = "2044--2047",

journal = "Allergy",

issn = "0105-4538",

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}

Haasnoot, ML, Kleuskens, MTA , Lopez-Rincon, A , Diks, MAP, Terreehorst, I, Akkerdaas, JH, van Ree, R, van Ampting, MTJ, Garssen, J , Redegeld, FA , van Esch, BCAM & Bredenoord, AJ 2023, 'In vivo and ex vivo inflammatory responses of the esophageal mucosa to food challenge in adults with eosinophilic esophagitis', Allergy, vol. 78, no. 7, pp. 2044-2047. https://doi.org/10.1111/all.15694

TY - JOUR

T1 - In vivo and ex vivo inflammatory responses of the esophageal mucosa to food challenge in adults with eosinophilic esophagitis

AU - Haasnoot, Maria L

AU - Kleuskens, Mirelle T A

AU - Lopez-Rincon, Alejandro

AU - Diks, Mara A P

AU - Terreehorst, Ingrid

AU - Akkerdaas, Jaap H

AU - van Ree, Ronald

AU - van Ampting, Marleen T J

AU - Garssen, Johan

AU - Redegeld, Frank A

AU - van Esch, Betty C A M

AU - Bredenoord, Albert J

N1 - Funding Information: This research is funded within the Partnership between NWO domain Applied and Engineered Sciences and Danone Nutricia Research and with additional financial support from Topsector Agri and Food, project number 16495 with the acronym LOIRE. AJB is supported by Vidi grant 91718300 from the Netherlands Organization for Scientific Research NWO. Funding Information: AJB received research funding from Norgine, Thelial, SST and received speaker and/or consulting fees from Laborie, Arena, EsoCap, Medtronic, Dr. Falk Pharma, Calypso Biotech, Alimentiv, Sanofi, Reckett, Regeneron and AstraZeneca (all unrelated to this work). RvR received consultancy fees from HAL Allergy, Citeq, Angany, Reacta Healthcare, Mission MightyMe and AB Enzymes, speaker fees from HAL Allergy, ThermoFisher Scientific and ALK, and has stock option of Angany (all unrelated to this work). MTJVA is employed by Danone Nutricia Research. JG and BCAMVE are partly employed by Danone Nutricia Research. All other authors report no conflict of interest. Funding Information: AJB received research funding from Norgine, Thelial, SST and received speaker and/or consulting fees from Laborie, Arena, EsoCap, Medtronic, Dr. Falk Pharma, Calypso Biotech, Alimentiv, Sanofi, Reckett, Regeneron and AstraZeneca (all unrelated to this work). RvR received consultancy fees from HAL Allergy, Citeq, Angany, Reacta Healthcare, Mission MightyMe and AB Enzymes, speaker fees from HAL Allergy, ThermoFisher Scientific and ALK, and has stock option of Angany (all unrelated to this work). MTJVA is employed by Danone Nutricia Research. JG and BCAMVE are partly employed by Danone Nutricia Research. All other authors report no conflict of interest. This research is funded within the Partnership between NWO domain Applied and Engineered Sciences and Danone Nutricia Research and with additional financial support from Topsector Agri and Food, project number 16495 with the acronym LOIRE. AJB is supported by Vidi grant 91718300 from the Netherlands Organization for Scientific Research NWO.

PY - 2023/7

Y1 - 2023/7

KW - Adult

KW - Enteritis

KW - Eosinophilic Esophagitis/diagnosis

KW - Esophageal Mucosa

KW - Food/adverse effects

KW - Humans

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U2 - 10.1111/all.15694

DO - 10.1111/all.15694

M3 - Comment/Letter to the editor

C2 - 36869622

SN - 0105-4538

VL - 78

SP - 2044

EP - 2047

JO - Allergy

JF - Allergy

IS - 7

ER -

In vivo and ex vivo inflammatory responses of the esophageal mucosa to food challenge in adults with eosinophilic esophagitis

Bibliographical note

Funding

Keywords

Access to Document

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Cite this