In vitro and in silico optimization of oral taxane therapy

Keyphrases

• Taxanes 100%
• Docetaxel 100%
• Taxane Therapy 100%
• In-silico Optimization 100%
• Oral Formulation 75%
• Route of Administration 50%
• Plasma Concentration 50%
• Paclitaxel 50%
• Treatment Efficacy 50%
• Solid Tumors 50%
• Cabazitaxel 50%
• Oral Docetaxel 25%
• Ritonavir 25%
• Knowledge Gaps 25%
• Intestine 25%
• Mathematical Model 25%
• Enzyme Inhibitors 25%
• Liver 25%
• Genetic Differences 25%
• Breast Cancer Cells 25%
• Specific Enzymes 25%
• Administration Schedule 25%
• Tumor Subtype 25%
• Relevant Knowledge 25%
• Effective Alternative 25%
• Patient-centered 25%
• Treatment Optimization 25%
• Starting Dose 25%
• Intravenous Route 25%
• Treatment Toxicity 25%
• Weekly Schedule 25%
• First-in-human Study 25%
• Patient Costs 25%
• Weekly Docetaxel 25%
• Bone Marrow Toxicity 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Docetaxel 100%
• Taxane 100%
• Paclitaxel 33%
• Solid Malignant Neoplasm 33%
• Cabazitaxel 33%
• Combination Therapy 33%
• Route of Administration 16%
• Human Study 16%
• Intravenous Route 16%
• Ritonavir 16%
• Breast Cancer 16%
• Bone Marrow Toxicity 16%
• Enzyme Inhibitor 16%