Impaired immune function: An early marker for cancer cachexia

Joyce Faber, Arjan P. Vos, Diane Kegler, Josep Argilés, Alessandro Laviano, Johan Garssen, Ardy Van Helvoort

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Cachexia and chronic inflammation are major challenges for cancer patients, leading to serious consequences. Accordingly, it is of high clinical relevance to identify early risk factors for optimal treatment, as these are currently not available. The present study demonstrates a strong decline in contact hypersensitivity, a parameter for cell-mediated immunity, in tumor-bearing cachectic mice. Interestingly, a significant reduction was already observed during the pre-cachectic state, reflecting an impaired immune function prior to weight loss. Extrapolating to the human setting, reduced immune competence of cancer patients could serve as an early marker for cancer cachexia, enabling an early supportive care strategy.
Original languageEnglish
Pages (from-to)1403-1406
Number of pages4
JournalOncology Reports
Volume22
Issue number6
DOIs
Publication statusPublished - 14 Jun 2009

Keywords

  • Cachexia
  • Cancer
  • Immune function
  • Inflammation
  • Nutrition
  • animal cell
  • animal experiment
  • animal model
  • article
  • cachexia
  • cellular immunity
  • contact allergy
  • controlled study
  • disease marker
  • immune deficiency
  • immunocompetence
  • male
  • mouse
  • nonhuman
  • priority journal
  • weight reduction

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