Immunomodulatory effects of amino acid-based formulae (AAF) in gastrointestinal non-IgE mediated food allergy

Anita Hartog; Hannah E. Jones; Lucien F. Harthoorn; Johan Garssen; Holly Stephenson; Katja Brunner; Jutta Köglmeier; Neil Shah; Mona Bajaj-Elliot; Keith J. Lindley

doi:10.1016/j.jaci.2014.12.1890

Immunomodulatory effects of amino acid-based formulae (AAF) in gastrointestinal non-IgE mediated food allergy

Anita Hartog, Hannah E. Jones, Lucien F. Harthoorn, Johan Garssen, Holly Stephenson, Katja Brunner, Jutta Köglmeier, Neil Shah, Mona Bajaj-Elliot, Keith J. Lindley

Pharmacology

Research output: Contribution to journal › Meeting Abstract › Academic

Abstract

RATIONALE: Management of non-IgE mediated food allergies in early childhood involves allergen avoidance by using extensively hydrolysed (eHF) or amino acid-based formulas (AAF). Clinical anecdote suggests that AAF relieve symptoms more effectively in some patients than using eHF or simple allergen avoidance. This study aimed to explore whether AAF has additional immunomodulatory properties. METHODS: Forty-eight pediatric patients (

Original language	English
Pages (from-to)	386
Number of pages	1
Journal	Journal of Allergy and Clinical Immunology
Volume	135
Issue number	2
DOIs	https://doi.org/10.1016/j.jaci.2014.12.1890
Publication status	Published - 1 Feb 2015

Keywords

amino acid
immunoglobulin E
cytokine
glycine
lipopolysaccharide
allergen
protein
interleukin 12
glutamine
interleukin 6
interleukin 4
food allergy
American
allergic asthma
immunology
human
patient
neutrophil chemotaxis
supplementation
assay
colon biopsy
immunity
child
biopsy
wheat
diet
egg
basophil
milk
rat
peripheral blood mononuclear cell
childhood
blood
cellular immunity
leukemia cell
cerebrospinal fluid
enzyme linked immunosorbent assay

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10.1016/j.jaci.2014.12.1890

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title = "Immunomodulatory effects of amino acid-based formulae (AAF) in gastrointestinal non-IgE mediated food allergy",

abstract = "RATIONALE: Management of non-IgE mediated food allergies in early childhood involves allergen avoidance by using extensively hydrolysed (eHF) or amino acid-based formulas (AAF). Clinical anecdote suggests that AAF relieve symptoms more effectively in some patients than using eHF or simple allergen avoidance. This study aimed to explore whether AAF has additional immunomodulatory properties. METHODS: Forty-eight pediatric patients (",

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author = "Anita Hartog and Jones, {Hannah E.} and Harthoorn, {Lucien F.} and Johan Garssen and Holly Stephenson and Katja Brunner and Jutta K{\"o}glmeier and Neil Shah and Mona Bajaj-Elliot and Lindley, {Keith J.}",

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doi = "10.1016/j.jaci.2014.12.1890",

language = "English",

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T1 - Immunomodulatory effects of amino acid-based formulae (AAF) in gastrointestinal non-IgE mediated food allergy

AU - Hartog, Anita

AU - Jones, Hannah E.

AU - Harthoorn, Lucien F.

AU - Garssen, Johan

AU - Stephenson, Holly

AU - Brunner, Katja

AU - Köglmeier, Jutta

AU - Shah, Neil

AU - Bajaj-Elliot, Mona

AU - Lindley, Keith J.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - RATIONALE: Management of non-IgE mediated food allergies in early childhood involves allergen avoidance by using extensively hydrolysed (eHF) or amino acid-based formulas (AAF). Clinical anecdote suggests that AAF relieve symptoms more effectively in some patients than using eHF or simple allergen avoidance. This study aimed to explore whether AAF has additional immunomodulatory properties. METHODS: Forty-eight pediatric patients (

AB - RATIONALE: Management of non-IgE mediated food allergies in early childhood involves allergen avoidance by using extensively hydrolysed (eHF) or amino acid-based formulas (AAF). Clinical anecdote suggests that AAF relieve symptoms more effectively in some patients than using eHF or simple allergen avoidance. This study aimed to explore whether AAF has additional immunomodulatory properties. METHODS: Forty-eight pediatric patients (

KW - amino acid

KW - immunoglobulin E

KW - cytokine

KW - glycine

KW - lipopolysaccharide

KW - allergen

KW - protein

KW - interleukin 12

KW - glutamine

KW - interleukin 6

KW - interleukin 4

KW - food allergy

KW - American

KW - allergic asthma

KW - immunology

KW - human

KW - patient

KW - neutrophil chemotaxis

KW - supplementation

KW - assay

KW - colon biopsy

KW - immunity

KW - child

KW - biopsy

KW - wheat

KW - diet

KW - egg

KW - basophil

KW - milk

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KW - peripheral blood mononuclear cell

KW - childhood

KW - blood

KW - cellular immunity

KW - leukemia cell

KW - cerebrospinal fluid

KW - enzyme linked immunosorbent assay

U2 - 10.1016/j.jaci.2014.12.1890

DO - 10.1016/j.jaci.2014.12.1890

M3 - Meeting Abstract

SN - 0091-6749

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SP - 386

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 2

ER -

Immunomodulatory effects of amino acid-based formulae (AAF) in gastrointestinal non-IgE mediated food allergy

Abstract

Keywords

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