Imaging Mass Spectrometry-based Molecular Histology Differentiates Microscopically Identical and Heterogeneous Tumors

E.A. Jones; N. Schmitz; C.J.F. Waaijer; C. Frese; A. van Remoortere; R.J.M. van Zeijl; A.J.R. Heck; P.C.W. Hogendoorn; A.M. Deelder; A.F.M. Altelaar; J.V.M.G. Bovée; L.A. McDonnell

doi:10.1021/pr301190g

Imaging Mass Spectrometry-based Molecular Histology Differentiates Microscopically Identical and Heterogeneous Tumors

E.A. Jones, N. Schmitz, C.J.F. Waaijer, C. Frese, A. van Remoortere, R.J.M. van Zeijl, A.J.R. Heck, P.C.W. Hogendoorn, A.M. Deelder, A.F.M. Altelaar, J.V.M.G. Bovée, L.A. McDonnell

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Many tumors display significant cellular heterogeneity as well as molecular heterogeneity. Sensitive biomarkers that differentiate between diagnostically challenging tumors must contend with this heterogeneity. Mass spectrometry-based molecular histology of a patient series of heterogeneous, microscopically identical bone tumors highlighted the tumor cell types that could be characterized by a single profile and led to the identification of specific peptides that differentiate between the tumors.

Original language	English
Pages (from-to)	1847-1855
Number of pages	9
Journal	Journal of Proteome Research
Volume	12
DOIs	https://doi.org/10.1021/pr301190g
Publication status	Published - 2013

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Jones, E. A., Schmitz, N., Waaijer, C. J. F., Frese, C., van Remoortere, A., van Zeijl, R. J. M., Heck, A. J. R., Hogendoorn, P. C. W., Deelder, A. M., Altelaar, A. F. M., Bovée, J. V. M. G., & McDonnell, L. A. (2013). Imaging Mass Spectrometry-based Molecular Histology Differentiates Microscopically Identical and Heterogeneous Tumors. Journal of Proteome Research, 12, 1847-1855. https://doi.org/10.1021/pr301190g

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title = "Imaging Mass Spectrometry-based Molecular Histology Differentiates Microscopically Identical and Heterogeneous Tumors",

abstract = "Many tumors display significant cellular heterogeneity as well as molecular heterogeneity. Sensitive biomarkers that differentiate between diagnostically challenging tumors must contend with this heterogeneity. Mass spectrometry-based molecular histology of a patient series of heterogeneous, microscopically identical bone tumors highlighted the tumor cell types that could be characterized by a single profile and led to the identification of specific peptides that differentiate between the tumors.",

author = "E.A. Jones and N. Schmitz and C.J.F. Waaijer and C. Frese and {van Remoortere}, A. and {van Zeijl}, R.J.M. and A.J.R. Heck and P.C.W. Hogendoorn and A.M. Deelder and A.F.M. Altelaar and J.V.M.G. Bov{\'e}e and L.A. McDonnell",

year = "2013",

doi = "10.1021/pr301190g",

language = "English",

volume = "12",

pages = "1847--1855",

journal = "Journal of Proteome Research",

issn = "1535-3893",

publisher = "American Chemical Society",

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Jones, EA, Schmitz, N, Waaijer, CJF, Frese, C, van Remoortere, A, van Zeijl, RJM, Heck, AJR, Hogendoorn, PCW, Deelder, AM, Altelaar, AFM, Bovée, JVMG & McDonnell, LA 2013, 'Imaging Mass Spectrometry-based Molecular Histology Differentiates Microscopically Identical and Heterogeneous Tumors', Journal of Proteome Research, vol. 12, pp. 1847-1855. https://doi.org/10.1021/pr301190g

TY - JOUR

T1 - Imaging Mass Spectrometry-based Molecular Histology Differentiates Microscopically Identical and Heterogeneous Tumors

AU - Jones, E.A.

AU - Schmitz, N.

AU - Waaijer, C.J.F.

AU - Frese, C.

AU - van Remoortere, A.

AU - van Zeijl, R.J.M.

AU - Heck, A.J.R.

AU - Hogendoorn, P.C.W.

AU - Deelder, A.M.

AU - Altelaar, A.F.M.

AU - Bovée, J.V.M.G.

AU - McDonnell, L.A.

PY - 2013

Y1 - 2013

N2 - Many tumors display significant cellular heterogeneity as well as molecular heterogeneity. Sensitive biomarkers that differentiate between diagnostically challenging tumors must contend with this heterogeneity. Mass spectrometry-based molecular histology of a patient series of heterogeneous, microscopically identical bone tumors highlighted the tumor cell types that could be characterized by a single profile and led to the identification of specific peptides that differentiate between the tumors.

AB - Many tumors display significant cellular heterogeneity as well as molecular heterogeneity. Sensitive biomarkers that differentiate between diagnostically challenging tumors must contend with this heterogeneity. Mass spectrometry-based molecular histology of a patient series of heterogeneous, microscopically identical bone tumors highlighted the tumor cell types that could be characterized by a single profile and led to the identification of specific peptides that differentiate between the tumors.

U2 - 10.1021/pr301190g

DO - 10.1021/pr301190g

M3 - Article

SN - 1535-3893

VL - 12

SP - 1847

EP - 1855

JO - Journal of Proteome Research

JF - Journal of Proteome Research

ER -

Imaging Mass Spectrometry-based Molecular Histology Differentiates Microscopically Identical and Heterogeneous Tumors

Abstract

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