Skip to main navigation Skip to search Skip to main content

Identification of two new serum protein profiles for renal cell carcinoma

  • J. Engwegen
  • , N. Mehra
  • , J. Haanen
  • , J.H.M. Schellens
  • , E.E. Voest
  • , J.H. Beijnen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Renal cell carcinoma (RCC) is the most lethal urological cancer, and survival greatly depends on early diagnosis. Therefore, reliable, new biomarkers for detection of RCC are required. We assessed serum protein profiles of samples from two institutes with SELDI-TOF MS in duplicate on CM 10 chips at pH 6.0 (set 1:37 RCC + 32 healthy controls (HC), set 2: 20 RCC + 25 HC). Mean peak intensities of detected proteins were compared between RCC and HC with non-parametric testing. Classification trees were built with discriminating peaks using one sample set as training set and the other as independent validation set. We found 15 peaks significantly different (p
Original languageUndefined/Unknown
Pages (from-to)401-408
Number of pages8
JournalOncology Reports
Volume22
Issue number2
Publication statusPublished - 2009

Bibliographical note

ISI:000267858200024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Cite this