Identification of novel factors that promote spindle positioning in the C. elegans embryo

C.W.H. Berends

Identification of novel factors that promote spindle positioning in the C. elegans embryo

C.W.H. Berends

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Abstract

LIN-5, GPR-1/2, and the Ga proteins GOA-1 and GPA-16, have previously been identified as key regulators of spindle positioning. In this thesis we identified other components that contribute to the different spindle and nuclear positioning events in the early embryo, either acting together, or independently of the LIN-5 complex. The link to mitochondria and the ER in these processes was surprising. The combined results in this thesis emphasize that in addition to cortical microtubule interactions, different cellular organelles could provide localized cues that contribute to spindle and nuclear positioning

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Utrecht University
Supervisors/Advisors	van den Heuvel, Sander, Primary supervisor
Award date	28 Aug 2012
Publisher	Utrecht University
Publication status	Published - 28 Aug 2012

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title = "Identification of novel factors that promote spindle positioning in the C. elegans embryo",

abstract = "LIN-5, GPR-1/2, and the Ga proteins GOA-1 and GPA-16, have previously been identified as key regulators of spindle positioning. In this thesis we identified other components that contribute to the different spindle and nuclear positioning events in the early embryo, either acting together, or independently of the LIN-5 complex. The link to mitochondria and the ER in these processes was surprising. The combined results in this thesis emphasize that in addition to cortical microtubule interactions, different cellular organelles could provide localized cues that contribute to spindle and nuclear positioning",

author = "C.W.H. Berends",

year = "2012",

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language = "English",

publisher = "Utrecht University",

type = "Doctoral thesis 1 (Research UU / Graduation UU)",

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AU - Berends, C.W.H.

PY - 2012/8/28

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N2 - LIN-5, GPR-1/2, and the Ga proteins GOA-1 and GPA-16, have previously been identified as key regulators of spindle positioning. In this thesis we identified other components that contribute to the different spindle and nuclear positioning events in the early embryo, either acting together, or independently of the LIN-5 complex. The link to mitochondria and the ER in these processes was surprising. The combined results in this thesis emphasize that in addition to cortical microtubule interactions, different cellular organelles could provide localized cues that contribute to spindle and nuclear positioning

AB - LIN-5, GPR-1/2, and the Ga proteins GOA-1 and GPA-16, have previously been identified as key regulators of spindle positioning. In this thesis we identified other components that contribute to the different spindle and nuclear positioning events in the early embryo, either acting together, or independently of the LIN-5 complex. The link to mitochondria and the ER in these processes was surprising. The combined results in this thesis emphasize that in addition to cortical microtubule interactions, different cellular organelles could provide localized cues that contribute to spindle and nuclear positioning

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

PB - Utrecht University

ER -

Identification of novel factors that promote spindle positioning in the C. elegans embryo

Abstract

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