Identification and transmission of hepatitis B virus-related variants

J. R. Wands; Y. K. Fujita; K. J. Isselbacher; C. Degott; H. Schellekens; M. C. Dazza; V. Thiers; P. Tiollais; C. Brechot

doi:10.1073/pnas.83.17.6608

Identification and transmission of hepatitis B virus-related variants

J. R. Wands
, Y. K. Fujita
, K. J. Isselbacher
, C. Degott
, H. Schellekens
, M. C. Dazza
, V. Thiers
, P. Tiollais
, C. Brechot

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We have identified long-incubation viral agents that share epitopes with hepatitis B virus (HBV). During chimpanzee infectivity studies, these agents may be recognized in the liver since they possess complementary nucleic acid sequences with HBV DNA; the genomic size was found to be 3.2 kilobases, identical to that of HBV. Liver injury was produced and there was antigen expression in hepatocytes. Chimpanzees were not protected by prior immunization with hepatitis B surface antigen; conversely, they were still susceptible to HBV after recovery from infection with such agents. These findings suggest that these hepatitis B virus-related variants appear to be immunologically distinct from HBV.

Original language	English
Pages (from-to)	6608-6612
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	83
Issue number	17
DOIs	https://doi.org/10.1073/pnas.83.17.6608
Publication status	Published - 1 Dec 1986
Externally published	Yes

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10.1073/pnas.83.17.6608

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title = "Identification and transmission of hepatitis B virus-related variants",

abstract = "We have identified long-incubation viral agents that share epitopes with hepatitis B virus (HBV). During chimpanzee infectivity studies, these agents may be recognized in the liver since they possess complementary nucleic acid sequences with HBV DNA; the genomic size was found to be 3.2 kilobases, identical to that of HBV. Liver injury was produced and there was antigen expression in hepatocytes. Chimpanzees were not protected by prior immunization with hepatitis B surface antigen; conversely, they were still susceptible to HBV after recovery from infection with such agents. These findings suggest that these hepatitis B virus-related variants appear to be immunologically distinct from HBV.",

author = "Wands, \{J. R.\} and Fujita, \{Y. K.\} and Isselbacher, \{K. J.\} and C. Degott and H. Schellekens and Dazza, \{M. C.\} and V. Thiers and P. Tiollais and C. Brechot",

year = "1986",

month = dec,

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doi = "10.1073/pnas.83.17.6608",

language = "English",

volume = "83",

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journal = "Proceedings of the National Academy of Sciences of the United States of America",

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TY - JOUR

T1 - Identification and transmission of hepatitis B virus-related variants

AU - Wands, J. R.

AU - Fujita, Y. K.

AU - Isselbacher, K. J.

AU - Degott, C.

AU - Schellekens, H.

AU - Dazza, M. C.

AU - Thiers, V.

AU - Tiollais, P.

AU - Brechot, C.

PY - 1986/12/1

Y1 - 1986/12/1

N2 - We have identified long-incubation viral agents that share epitopes with hepatitis B virus (HBV). During chimpanzee infectivity studies, these agents may be recognized in the liver since they possess complementary nucleic acid sequences with HBV DNA; the genomic size was found to be 3.2 kilobases, identical to that of HBV. Liver injury was produced and there was antigen expression in hepatocytes. Chimpanzees were not protected by prior immunization with hepatitis B surface antigen; conversely, they were still susceptible to HBV after recovery from infection with such agents. These findings suggest that these hepatitis B virus-related variants appear to be immunologically distinct from HBV.

AB - We have identified long-incubation viral agents that share epitopes with hepatitis B virus (HBV). During chimpanzee infectivity studies, these agents may be recognized in the liver since they possess complementary nucleic acid sequences with HBV DNA; the genomic size was found to be 3.2 kilobases, identical to that of HBV. Liver injury was produced and there was antigen expression in hepatocytes. Chimpanzees were not protected by prior immunization with hepatitis B surface antigen; conversely, they were still susceptible to HBV after recovery from infection with such agents. These findings suggest that these hepatitis B virus-related variants appear to be immunologically distinct from HBV.

UR - https://www.scopus.com/pages/publications/0010501704

U2 - 10.1073/pnas.83.17.6608

DO - 10.1073/pnas.83.17.6608

M3 - Article

C2 - 3462716

AN - SCOPUS:0010501704

SN - 0027-8424

VL - 83

SP - 6608

EP - 6612

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 17

ER -

Identification and transmission of hepatitis B virus-related variants

Abstract

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