Identification and quantification of drug-albumin adducts in serum samples from a drug exposure study in mice

Keyphrases

• Serum Samples 100%
• Drug Exposure 100%
• Mouse Serum 100%
• Exposure Study 100%
• N-acetyl-p-benzoquinone Imine 100%
• Albumin Adducts 100%
• Albumin 66%
• Human Serum Albumin 66%
• Serum Albumin 66%
• Cysteine 34 66%
• Drug Toxicity 66%
• Protein Adducts 66%
• Free Cysteine 66%
• Affinity Chromatography 33%
• Sample Pretreatment 33%
• Drug Development 33%
• Selective Extraction 33%
• Drug Binding 33%
• Low Abundance 33%
• Protein-based 33%
• Adverse Drug Reaction 33%
• Drug Discovery 33%
• Bioactivation 33%
• Modified Proteins 33%
• LC-MS Analysis 33%
• Exposure Experiment 33%
• Tryptic Peptides 33%
• Tryptic Digestion 33%
• Adduct Formation 33%
• Binding Studies 33%
• Reactive Metabolites 33%
• Free Cysteine Residue 33%
• Acetaminophen APAP 33%
• Optimization Strategy 33%
• Complex Biological Samples 33%
• Major Complications 33%
• Targeted Analysis 33%
• Gel Filtration Chromatography 33%
• Covalent Inhibitor 33%
• Reactive Drug Metabolites 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Cysteine 100%
• Albumin 100%
• Acetic Acid Derivative 60%
• Human Serum Albumin 40%
• Drug Toxicity 40%
• Serum Albumin 40%
• Adverse Drug Reaction 20%
• Drug Development 20%
• Bioactivation 20%
• Drug Discovery 20%
• Drug Metabolite 20%
• Paracetamol 20%