Identification and characterization of two novel viruses in ocular infections in reindeer

Saskia L Smits, Claudia M E Schapendonk, Marije van Leeuwen, Thijs Kuiken, Rogier Bodewes, V Stalin Raj, Bart L Haagmans, Carlos G das Neves, Morten Tryland, Albert D M E Osterhaus

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A thorough understanding of virus diversity in wildlife provides epidemiological baseline information about pathogens. In this study, eye swab samples were obtained from semi-domesticated reindeer (Rangifertarandus tarandus) in Norway during an outbreak of infectious eye disease, possibly a very early stage of infectious keratoconjunctivitis (IKC). Large scale molecular virus screening, based on host nucleic acid depletion, sequence-independent amplification and next-generation sequencing of partially purified viral nucleic acid, revealed the presence of a new papillomavirus in 2 out of 8 eye swab samples and a new betaherpesvirus in 3 out of 8 eye swab samples collected from animals with clinical signs and not in similar samples in 9 animals without clinical signs. Whether either virus was responsible for causing the clinical signs or in any respect was associated to the disease condition remains to be determined.

Original languageEnglish
Pages (from-to)e69711
JournalPLoS One
Volume8
Issue number7
DOIs
Publication statusPublished - 2013

Keywords

  • Animals
  • Eye Infections
  • Papillomaviridae
  • Phylogeny
  • Reindeer

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