Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy

Adolfo López-Noriega; Conn L. Hastings; Burcin Ozbakir; Kathleen E. O'Donnell; Fergal J. O'Brien; G Storm; Wim E. Hennink; Garry P. Duffy; Eduardo Ruiz-Hernández

doi:10.1002/adhm.201300649

Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy

Adolfo López-Noriega, Conn L. Hastings, Burcin Ozbakir, Kathleen E. O'Donnell, Fergal J. O'Brien, G Storm, Wim E. Hennink, Garry P. Duffy^*, Eduardo Ruiz-Hernández

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy.

Original language	English
Pages (from-to)	854-859
Number of pages	6
Journal	Advanced healthcare materials
Volume	3
Issue number	6
DOIs	https://doi.org/10.1002/adhm.201300649
Publication status	Published - 1 Jan 2014

Keywords

Chemotherapy
Chitosan hydrogels
Hyperthermia
Liposomes
Thermoresponsive

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10.1002/adhm.201300649

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title = "Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy",

abstract = "A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy. ",

keywords = "Chemotherapy, Chitosan hydrogels, Hyperthermia, Liposomes, Thermoresponsive",

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AU - López-Noriega, Adolfo

AU - Hastings, Conn L.

AU - Ozbakir, Burcin

AU - O'Donnell, Kathleen E.

AU - O'Brien, Fergal J.

AU - Storm, G

AU - Hennink, Wim E.

AU - Duffy, Garry P.

AU - Ruiz-Hernández, Eduardo

PY - 2014/1/1

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N2 - A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy.

AB - A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy.

KW - Chemotherapy

KW - Chitosan hydrogels

KW - Hyperthermia

KW - Liposomes

KW - Thermoresponsive

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DO - 10.1002/adhm.201300649

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JO - Advanced healthcare materials

JF - Advanced healthcare materials

IS - 6

ER -

Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy

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