Human milk fatty acid composition of allergic and non-allergic mothers: The ulm spatz health study

Linda P. Siziba; Leonie Lorenz; Bernd Stahl; Marko Mank; Tamas Marosvölgyi; Tamas Decsi; Dietrich Rothenbacher; Jon Genuneit

doi:10.3390/nu12061740

Human milk fatty acid composition of allergic and non-allergic mothers: The ulm spatz health study

Linda P. Siziba^*, Leonie Lorenz, Bernd Stahl, Marko Mank, Tamas Marosvölgyi, Tamas Decsi, Dietrich Rothenbacher, Jon Genuneit

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The aim of this study was to determine the differences in human milk fatty acid composition in relation to maternal allergy within a large birth cohort study using statistical methods accounting for the correlations that exist in compositional data. We observed marginal differences in human milk fatty acid composition of allergic and non-allergic mothers. However, our results do not support the hypothesis that human milk fatty acid composition is influenced by allergy or that it differs between mothers with or without allergy. Observed differences in our results between transformed and untransformed fatty acid data call for re-evaluation of previous, as well as future, studies using statistical methods appropriate for compositionality of fatty acid data.

Original language	English
Article number	1740
Number of pages	8
Journal	Nutrients
Volume	12
Issue number	6
DOIs	https://doi.org/10.3390/nu12061740
Publication status	Published - Jun 2020

Keywords

Fatty acids
Human milk
Maternal allergy

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abstract = "The aim of this study was to determine the differences in human milk fatty acid composition in relation to maternal allergy within a large birth cohort study using statistical methods accounting for the correlations that exist in compositional data. We observed marginal differences in human milk fatty acid composition of allergic and non-allergic mothers. However, our results do not support the hypothesis that human milk fatty acid composition is influenced by allergy or that it differs between mothers with or without allergy. Observed differences in our results between transformed and untransformed fatty acid data call for re-evaluation of previous, as well as future, studies using statistical methods appropriate for compositionality of fatty acid data.",

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AU - Siziba, Linda P.

AU - Lorenz, Leonie

AU - Stahl, Bernd

AU - Mank, Marko

AU - Marosvölgyi, Tamas

AU - Decsi, Tamas

AU - Rothenbacher, Dietrich

AU - Genuneit, Jon

PY - 2020/6

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N2 - The aim of this study was to determine the differences in human milk fatty acid composition in relation to maternal allergy within a large birth cohort study using statistical methods accounting for the correlations that exist in compositional data. We observed marginal differences in human milk fatty acid composition of allergic and non-allergic mothers. However, our results do not support the hypothesis that human milk fatty acid composition is influenced by allergy or that it differs between mothers with or without allergy. Observed differences in our results between transformed and untransformed fatty acid data call for re-evaluation of previous, as well as future, studies using statistical methods appropriate for compositionality of fatty acid data.

AB - The aim of this study was to determine the differences in human milk fatty acid composition in relation to maternal allergy within a large birth cohort study using statistical methods accounting for the correlations that exist in compositional data. We observed marginal differences in human milk fatty acid composition of allergic and non-allergic mothers. However, our results do not support the hypothesis that human milk fatty acid composition is influenced by allergy or that it differs between mothers with or without allergy. Observed differences in our results between transformed and untransformed fatty acid data call for re-evaluation of previous, as well as future, studies using statistical methods appropriate for compositionality of fatty acid data.

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Human milk fatty acid composition of allergic and non-allergic mothers: The ulm spatz health study

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Keywords

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