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Human Milk and Allergic Diseases: An Unsolved Puzzle

  • Daniel Munblit
  • , Diego G Peroni
  • , Alba Boix-Amorós
  • , Peter S Hsu
  • , Belinda Van't Land
  • , Melvin C L Gay
  • , Anastasia Kolotilina
  • , Chrysanthi Skevaki
  • , Robert J Boyle
  • , Maria Carmen Collado
  • , Johan Garssen
  • , Donna T Geddes
  • , Ralph Nanan
  • , Carolyn Slupsky
  • , Ganesa Wegienka
  • , Anita L. Kozyrskyj
  • , John O Warner
  • The In-FLAME Global Network, an Affiliate of the World Universities Network (WUN), West New York, NJ 07093, USA. [email protected].
  • Department of Clinical and Experimental Medicine, Section of Paediatrics, University of Pisa, 56126 Pisa, Italy. [email protected].
  • Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), 46980 Valencia, Spain. [email protected].
  • Allergy and Immunology, The Kids Research Institute, The Children's Hospital at Westmead, Sydney, NSW 2145, Australia. [email protected].
  • Department of Paediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, 3584 EA Utrecht, The Netherlands. [email protected].
  • School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia. [email protected].
  • Faculty of Pediatrics, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia. [email protected].
  • Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, University Hospital Giessen and Marburg GmbH Baldingerstr, 35043 Marburg, Germany. [email protected].
  • The In-FLAME Global Network, an Affiliate of the World Universities Network (WUN), West New York, NJ 07093, USA. [email protected].
  • Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), 46980 Valencia, Spain. [email protected].
  • Nutricia Research, 3584 CT Utrecht, The Netherlands. [email protected].
  • School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia. [email protected].
  • Charles Perkins Centre Nepean, University of Sydney, Sydney, NSW 2747, Australia. [email protected].
  • Department of Nutrition, University of California, Davis, CA 95616-5270, USA. [email protected].
  • Center for Urban Responses to Environmental Stressors, Detroit, MI 48202, USA. [email protected].
  • Department of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, Canada. [email protected].
  • National Institute for Health Research, Collaboration for Leadership in Applied Health Research and Care for NW London, London SW10 9NH, UK. [email protected].

Research output: Contribution to journal › Review article › peer-review

Abstract

There is conflicting evidence on the protective role of breastfeeding in relation to the development of allergic sensitisation and allergic disease. Studies vary in methodology and definition of outcomes, which lead to considerable heterogeneity. Human milk composition varies both within and between individuals, which may partially explain conflicting data. It is known that human milk composition is very complex and contains variable levels of immune active molecules, oligosaccharides, metabolites, vitamins and other nutrients and microbial content. Existing evidence suggests that modulation of human breast milk composition has potential for preventing allergic diseases in early life. In this review, we discuss associations between breastfeeding/human milk composition and allergy development.

Original languageEnglish
JournalNutrients
Volume9
Issue number8
DOIs
Publication statusPublished - 17 Aug 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • breastfeeding
  • human milk
  • allergy
  • allergic diseases
  • oligosaccharides
  • microbiome
  • cytokines
  • thymus

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