Hubungan Penggunaan Antimikroba terhadap Resistansi pada Peternakan Unggas Broiler Mandiri di Kabupaten Bogor

Nofita Nurbiyanti; Imron Suandy; Riana Aryani Arief; Putik Allamanda; Gian Pertela; Budi Purwanto; Hanan Daradjat; Nuraini Triwijayanti; Kanti Puji Rahayu; Oli Susanti; Riska Desitania; Rianna Anwar Sani; David Speksnijder; Tagrid Dinar; Tri Satya Putri Naipospos; Jaap Wagenaar

Hubungan Penggunaan Antimikroba terhadap Resistansi pada Peternakan Unggas Broiler Mandiri di Kabupaten Bogor

Translated title of the contribution: The Association of Antimicrobials Use with Resistance Incidence in Independent Broiler Poultry Farms in Bogor District

Nofita Nurbiyanti^*, Imron Suandy, Riana Aryani Arief, Putik Allamanda, Gian Pertela, Budi Purwanto, Hanan Daradjat, Nuraini Triwijayanti, Kanti Puji Rahayu, Oli Susanti, Riska Desitania, Rianna Anwar Sani, David Speksnijder, Tagrid Dinar, Tri Satya Putri Naipospos, Jaap Wagenaar

^*Corresponding author for this work

Clinical Infectiology

Research output: Contribution to journal › Article › Academic

Abstract

The use of antimicrobials in livestock selects for antimicrobials resistance in the livestock sector what is a potential threat for human health. This study aims to determine the association between antimicrobials use and the incidence of resistance in commensal Escherichia coli in Indonesian broiler farms. Data was collected on the use of antimicrobials for 4-6 production periods on 19 independent broiler farms in Bogor Regency from 2019 to 2022 (97 cycles). At the end of one of the last cycles, a boot swab sample of the bedding/litter was taken and 25 E. coli strains were isolated per farm. A total of 475 isolates of E. coli were tested with Susceptibility using the microdilution (Sensititre®) method for determining phenotypic resistance. The association between the antimicrobials used (Treatment Frequency Used Daily Dose/TFUDD) in the long term (97 cycles) and the short term (in the end cycle in which the sample was taken, 19 cycles) with the proportion of resistance was analyzed using linear regression. Farms most frequently used antimicrobials which were categorized as Highest Priority Critically Important Antimicrobials/HPCIA for human medicine (WHO, 2019). From 475 isolates of E. coli that were isolated, it was seen that the population of E. coli shows a high percentage of non-wildtype isolates (here called ‘resistant’). The highest resistance was seen to antimicrobials ciprofloxacin (93%), ampicillin (88%), tetracycline (83%), sulfamethoxazole (75%), and trimethoprim (71%). Of the 5 classes of antimicrobials analyzed, a significant association was found between the frequency of antimicrobials treatment and the proportion of resistance to quinolones and tetracyclines (p

Translated title of the contribution	The Association of Antimicrobials Use with Resistance Incidence in Independent Broiler Poultry Farms in Bogor District
Original language	Indonesian
Pages (from-to)	33-40
Number of pages	8
Journal	Acta VETERINARIA Indonesiana
Volume	2022
Publication status	Published - 8 Oct 2022

Keywords

antimicrobials use
antimicrobials resistance
broiler farm
Escherichia coli

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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42700-Article Text-193544-3-10-20221031Final published version, 328 KBLicence: CC BY-SA

https://journal.ipb.ac.id/index.php/actavetindones/article/view/42700Licence: CC BY-SA

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Nurbiyanti, N., Suandy, I., Arief, R. A., Allamanda, P., Pertela, G., Purwanto, B., Daradjat, H., Triwijayanti, N., Rahayu, K. P., Susanti, O., Desitania, R., Anwar Sani, R., Speksnijder, D., Dinar, T., Naipospos, T. S. P., & Wagenaar, J. (2022). Hubungan Penggunaan Antimikroba terhadap Resistansi pada Peternakan Unggas Broiler Mandiri di Kabupaten Bogor. Acta VETERINARIA Indonesiana, 2022, 33-40. https://journal.ipb.ac.id/index.php/actavetindones/article/view/42700

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title = "Hubungan Penggunaan Antimikroba terhadap Resistansi pada Peternakan Unggas Broiler Mandiri di Kabupaten Bogor",

abstract = "The use of antimicrobials in livestock selects for antimicrobials resistance in the livestock sector what is a potential threat for human health. This study aims to determine the association between antimicrobials use and the incidence of resistance in commensal Escherichia coli in Indonesian broiler farms. Data was collected on the use of antimicrobials for 4-6 production periods on 19 independent broiler farms in Bogor Regency from 2019 to 2022 (97 cycles). At the end of one of the last cycles, a boot swab sample of the bedding/litter was taken and 25 E. coli strains were isolated per farm. A total of 475 isolates of E. coli were tested with Susceptibility using the microdilution (Sensititre{\textregistered}) method for determining phenotypic resistance. The association between the antimicrobials used (Treatment Frequency Used Daily Dose/TFUDD) in the long term (97 cycles) and the short term (in the end cycle in which the sample was taken, 19 cycles) with the proportion of resistance was analyzed using linear regression. Farms most frequently used antimicrobials which were categorized as Highest Priority Critically Important Antimicrobials/HPCIA for human medicine (WHO, 2019). From 475 isolates of E. coli that were isolated, it was seen that the population of E. coli shows a high percentage of non-wildtype isolates (here called {\textquoteleft}resistant{\textquoteright}). The highest resistance was seen to antimicrobials ciprofloxacin (93%), ampicillin (88%), tetracycline (83%), sulfamethoxazole (75%), and trimethoprim (71%). Of the 5 classes of antimicrobials analyzed, a significant association was found between the frequency of antimicrobials treatment and the proportion of resistance to quinolones and tetracyclines (p",

keywords = "antimicrobials use, antimicrobials resistance, broiler farm, Escherichia coli",

author = "Nofita Nurbiyanti and Imron Suandy and Arief, {Riana Aryani} and Putik Allamanda and Gian Pertela and Budi Purwanto and Hanan Daradjat and Nuraini Triwijayanti and Rahayu, {Kanti Puji} and Oli Susanti and Riska Desitania and {Anwar Sani}, Rianna and David Speksnijder and Tagrid Dinar and Naipospos, {Tri Satya Putri} and Jaap Wagenaar",

year = "2022",

month = oct,

day = "8",

language = "Indonesian",

volume = "2022",

pages = "33--40",

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Nurbiyanti, N, Suandy, I, Arief, RA, Allamanda, P, Pertela, G, Purwanto, B, Daradjat, H, Triwijayanti, N, Rahayu, KP, Susanti, O, Desitania, R, Anwar Sani, R , Speksnijder, D, Dinar, T, Naipospos, TSP & Wagenaar, J 2022, 'Hubungan Penggunaan Antimikroba terhadap Resistansi pada Peternakan Unggas Broiler Mandiri di Kabupaten Bogor', Acta VETERINARIA Indonesiana, vol. 2022, pp. 33-40. <https://journal.ipb.ac.id/index.php/actavetindones/article/view/42700>

TY - JOUR

T1 - Hubungan Penggunaan Antimikroba terhadap Resistansi pada Peternakan Unggas Broiler Mandiri di Kabupaten Bogor

AU - Nurbiyanti, Nofita

AU - Suandy, Imron

AU - Arief, Riana Aryani

AU - Allamanda, Putik

AU - Pertela, Gian

AU - Purwanto, Budi

AU - Daradjat, Hanan

AU - Triwijayanti, Nuraini

AU - Rahayu, Kanti Puji

AU - Susanti, Oli

AU - Desitania, Riska

AU - Anwar Sani, Rianna

AU - Speksnijder, David

AU - Dinar, Tagrid

AU - Naipospos, Tri Satya Putri

AU - Wagenaar, Jaap

PY - 2022/10/8

Y1 - 2022/10/8

N2 - The use of antimicrobials in livestock selects for antimicrobials resistance in the livestock sector what is a potential threat for human health. This study aims to determine the association between antimicrobials use and the incidence of resistance in commensal Escherichia coli in Indonesian broiler farms. Data was collected on the use of antimicrobials for 4-6 production periods on 19 independent broiler farms in Bogor Regency from 2019 to 2022 (97 cycles). At the end of one of the last cycles, a boot swab sample of the bedding/litter was taken and 25 E. coli strains were isolated per farm. A total of 475 isolates of E. coli were tested with Susceptibility using the microdilution (Sensititre®) method for determining phenotypic resistance. The association between the antimicrobials used (Treatment Frequency Used Daily Dose/TFUDD) in the long term (97 cycles) and the short term (in the end cycle in which the sample was taken, 19 cycles) with the proportion of resistance was analyzed using linear regression. Farms most frequently used antimicrobials which were categorized as Highest Priority Critically Important Antimicrobials/HPCIA for human medicine (WHO, 2019). From 475 isolates of E. coli that were isolated, it was seen that the population of E. coli shows a high percentage of non-wildtype isolates (here called ‘resistant’). The highest resistance was seen to antimicrobials ciprofloxacin (93%), ampicillin (88%), tetracycline (83%), sulfamethoxazole (75%), and trimethoprim (71%). Of the 5 classes of antimicrobials analyzed, a significant association was found between the frequency of antimicrobials treatment and the proportion of resistance to quinolones and tetracyclines (p

AB - The use of antimicrobials in livestock selects for antimicrobials resistance in the livestock sector what is a potential threat for human health. This study aims to determine the association between antimicrobials use and the incidence of resistance in commensal Escherichia coli in Indonesian broiler farms. Data was collected on the use of antimicrobials for 4-6 production periods on 19 independent broiler farms in Bogor Regency from 2019 to 2022 (97 cycles). At the end of one of the last cycles, a boot swab sample of the bedding/litter was taken and 25 E. coli strains were isolated per farm. A total of 475 isolates of E. coli were tested with Susceptibility using the microdilution (Sensititre®) method for determining phenotypic resistance. The association between the antimicrobials used (Treatment Frequency Used Daily Dose/TFUDD) in the long term (97 cycles) and the short term (in the end cycle in which the sample was taken, 19 cycles) with the proportion of resistance was analyzed using linear regression. Farms most frequently used antimicrobials which were categorized as Highest Priority Critically Important Antimicrobials/HPCIA for human medicine (WHO, 2019). From 475 isolates of E. coli that were isolated, it was seen that the population of E. coli shows a high percentage of non-wildtype isolates (here called ‘resistant’). The highest resistance was seen to antimicrobials ciprofloxacin (93%), ampicillin (88%), tetracycline (83%), sulfamethoxazole (75%), and trimethoprim (71%). Of the 5 classes of antimicrobials analyzed, a significant association was found between the frequency of antimicrobials treatment and the proportion of resistance to quinolones and tetracyclines (p

KW - antimicrobials use

KW - antimicrobials resistance

KW - broiler farm

KW - Escherichia coli

M3 - Article

SN - 2337-4373

VL - 2022

SP - 33

EP - 40

JO - Acta VETERINARIA Indonesiana

JF - Acta VETERINARIA Indonesiana

ER -

Hubungan Penggunaan Antimikroba terhadap Resistansi pada Peternakan Unggas Broiler Mandiri di Kabupaten Bogor

Abstract

Keywords

UN SDGs

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