How to replace the oil droplet in Millikan's experiment with a single virus

Sanli Faez

doi:10.48550/arXiv.1601.01226

How to replace the oil droplet in Millikan's experiment with a single virus

Research output: Working paper › Preprint › Academic

Abstract

A highly sensitive optical capillary electrophoresis measurement method based on a nanofluidic optical fiber platform is presented. By using scaling arguments and considering realistic instrument limitations, I underline the feasibility of measuring the electrophoretic mobility of a single freely-diffusing nanoparticle or macromolecule in vitro, continuously and indefinitely, with microsecond time resolution. The high speed of this technique opens up new possibilities for studying reaction kinetics at the single molecule level.

Original language	English
Publisher	arXiv
Pages	1-4
Number of pages	4
DOIs	https://doi.org/10.48550/arXiv.1601.01226
Publication status	Published - Jan 2016

Keywords

Condensed Matter
Soft Condensed Matter
Physics
Optics
Colloids
Microscopy
Single molecule kinetics
Soft matter

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10.48550/arXiv.1601.01226

1601.01226v1Submitted manuscript, 953 KB

https://arxiv.org/abs/1601.01226v1

Cite this

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title = "How to replace the oil droplet in Millikan's experiment with a single virus",

abstract = "A highly sensitive optical capillary electrophoresis measurement method based on a nanofluidic optical fiber platform is presented. By using scaling arguments and considering realistic instrument limitations, I underline the feasibility of measuring the electrophoretic mobility of a single freely-diffusing nanoparticle or macromolecule in vitro, continuously and indefinitely, with microsecond time resolution. The high speed of this technique opens up new possibilities for studying reaction kinetics at the single molecule level.",

keywords = "Condensed Matter, Soft Condensed Matter, Physics, Optics, Colloids, Microscopy, Single molecule kinetics, Soft matter",

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N2 - A highly sensitive optical capillary electrophoresis measurement method based on a nanofluidic optical fiber platform is presented. By using scaling arguments and considering realistic instrument limitations, I underline the feasibility of measuring the electrophoretic mobility of a single freely-diffusing nanoparticle or macromolecule in vitro, continuously and indefinitely, with microsecond time resolution. The high speed of this technique opens up new possibilities for studying reaction kinetics at the single molecule level.

AB - A highly sensitive optical capillary electrophoresis measurement method based on a nanofluidic optical fiber platform is presented. By using scaling arguments and considering realistic instrument limitations, I underline the feasibility of measuring the electrophoretic mobility of a single freely-diffusing nanoparticle or macromolecule in vitro, continuously and indefinitely, with microsecond time resolution. The high speed of this technique opens up new possibilities for studying reaction kinetics at the single molecule level.

KW - Condensed Matter

KW - Soft Condensed Matter

KW - Physics

KW - Optics

KW - Colloids

KW - Microscopy

KW - Single molecule kinetics

KW - Soft matter

U2 - 10.48550/arXiv.1601.01226

DO - 10.48550/arXiv.1601.01226

M3 - Preprint

SP - 1

EP - 4

BT - How to replace the oil droplet in Millikan's experiment with a single virus

PB - arXiv

ER -

How to replace the oil droplet in Millikan's experiment with a single virus

Abstract

Keywords

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