How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Craig R G Willis; Marco Calvaruso; Debora Angeloni; Sarah Baatout; Alexandra Benchoua; Juergen Bereiter-Hahn; Daniele Bottai; Judith-Irina Buchheim; Eugénie Carnero-Diaz; Sara Castiglioni; Duccio Cavalieri; Gabriele Ceccarelli; Alexander Chouker; Francesca Cialdai; Gianni Ciofani; Giuseppe Coppola; Gabriella Cusella; Andrea Degl'Innocenti; Jean-Francois Desaphy; Jean-Pol Frippiat; Michael Gelinsky; Giada Genchi; Maria Grano; Daniela Grimm; Alain Guignandon; Raúl Herranz; Christine Hellweg; Carlo Saverio Iorio; Thodoris Karapantsios; Jack van Loon; Matteo Lulli; Jeanette Maier; Jos Malda; Emina Mamaca; Lucia Morbidelli; Andreas Osterman; Aleksandr Ovsianikov; Francesco Pampaloni; Elizabeth Pavezlorie; Veronica Pereda-Campos; Cyrille Przybyla; Petra Rettberg; Angela Maria Rizzo; Kate Robson-Brown; Leonardo Rossi; Giorgio Russo; Alessandra Salvetti; Chiara Risaliti; Daniela Santucci; Matthias Sperl; Kevin Tabury; Sara Tavella; Christiane Thielemann; Ronnie Willaert; Monica Monici; Nathaniel J Szewczyk

doi:10.1038/s41526-024-00395-3

How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Craig R G Willis, Marco Calvaruso, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Eugénie Carnero-Diaz, Sara Castiglioni, Duccio Cavalieri, Gabriele Ceccarelli, Alexander Chouker, Francesca Cialdai, Gianni Ciofani, Giuseppe Coppola, Gabriella Cusella, Andrea Degl'Innocenti, Jean-Francois Desaphy, Jean-Pol FrippiatMichael Gelinsky, Giada Genchi, Maria Grano, Daniela Grimm, Alain Guignandon, Raúl Herranz, Christine Hellweg, Carlo Saverio Iorio, Thodoris Karapantsios, Jack van Loon, Matteo Lulli, Jeanette Maier, Jos Malda, Emina Mamaca, Lucia Morbidelli, Andreas Osterman, Aleksandr Ovsianikov, Francesco Pampaloni, Elizabeth Pavezlorie, Veronica Pereda-Campos, Cyrille Przybyla, Petra Rettberg, Angela Maria Rizzo, Kate Robson-Brown, Leonardo Rossi, Giorgio Russo, Alessandra Salvetti, Chiara Risaliti, Daniela Santucci, Matthias Sperl, Kevin Tabury, Sara Tavella, Christiane Thielemann, Ronnie Willaert, Monica Monici, Nathaniel J Szewczyk^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, "Biology in Space and Analogue Environments", focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: "How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?" The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

Original language	English
Article number	50
Number of pages	5
Journal	npj Microgravity
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41526-024-00395-3
Publication status	Published - 1 May 2024

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

Funding

This manuscript has been written in the frame of the activities for the preparation and dissemination of the ESA-ROADMAPS FOR FUTURE RESEARCH which define strategic goals for future space research on the ISS and supporting research platforms. Support was granted to JIB and AC by the Federal Ministry of Economics and Technology/Climate Action [BMWi/K, 50WB1931 and 50WB2222].

Funders	Funder number
Bundesministerium für Wirtschaft und Technologie
Directorate-General for Climate Action	50WB1931, 50WB2222
Directorate-General for Climate Action

Access to Document

10.1038/s41526-024-00395-3Licence: CC BY

s41526-024-00395-3Final published version, 1.16 MBLicence: CC BY

Cite this

Willis, C. R. G., Calvaruso, M., Angeloni, D., Baatout, S., Benchoua, A., Bereiter-Hahn, J., Bottai, D., Buchheim, J.-I., Carnero-Diaz, E., Castiglioni, S., Cavalieri, D., Ceccarelli, G., Chouker, A., Cialdai, F., Ciofani, G., Coppola, G., Cusella, G., Degl'Innocenti, A., Desaphy, J.-F., ... Szewczyk, N. J. (2024). How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems? npj Microgravity, 10(1), Article 50. https://doi.org/10.1038/s41526-024-00395-3

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title = "How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?",

abstract = "Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, {"}Biology in Space and Analogue Environments{"}, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: {"}How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?{"} The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.",

author = "Willis, {Craig R G} and Marco Calvaruso and Debora Angeloni and Sarah Baatout and Alexandra Benchoua and Juergen Bereiter-Hahn and Daniele Bottai and Judith-Irina Buchheim and Eug{\'e}nie Carnero-Diaz and Sara Castiglioni and Duccio Cavalieri and Gabriele Ceccarelli and Alexander Chouker and Francesca Cialdai and Gianni Ciofani and Giuseppe Coppola and Gabriella Cusella and Andrea Degl'Innocenti and Jean-Francois Desaphy and Jean-Pol Frippiat and Michael Gelinsky and Giada Genchi and Maria Grano and Daniela Grimm and Alain Guignandon and Ra{\'u}l Herranz and Christine Hellweg and Iorio, {Carlo Saverio} and Thodoris Karapantsios and {van Loon}, Jack and Matteo Lulli and Jeanette Maier and Jos Malda and Emina Mamaca and Lucia Morbidelli and Andreas Osterman and Aleksandr Ovsianikov and Francesco Pampaloni and Elizabeth Pavezlorie and Veronica Pereda-Campos and Cyrille Przybyla and Petra Rettberg and Rizzo, {Angela Maria} and Kate Robson-Brown and Leonardo Rossi and Giorgio Russo and Alessandra Salvetti and Chiara Risaliti and Daniela Santucci and Matthias Sperl and Kevin Tabury and Sara Tavella and Christiane Thielemann and Ronnie Willaert and Monica Monici and Szewczyk, {Nathaniel J}",

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Willis, CRG, Calvaruso, M, Angeloni, D, Baatout, S, Benchoua, A, Bereiter-Hahn, J, Bottai, D, Buchheim, J-I, Carnero-Diaz, E, Castiglioni, S, Cavalieri, D, Ceccarelli, G, Chouker, A, Cialdai, F, Ciofani, G, Coppola, G, Cusella, G, Degl'Innocenti, A, Desaphy, J-F, Frippiat, J-P, Gelinsky, M, Genchi, G, Grano, M, Grimm, D, Guignandon, A, Herranz, R, Hellweg, C, Iorio, CS, Karapantsios, T, van Loon, J, Lulli, M, Maier, J, Malda, J, Mamaca, E, Morbidelli, L, Osterman, A, Ovsianikov, A, Pampaloni, F, Pavezlorie, E, Pereda-Campos, V, Przybyla, C, Rettberg, P, Rizzo, AM, Robson-Brown, K, Rossi, L, Russo, G, Salvetti, A, Risaliti, C, Santucci, D, Sperl, M, Tabury, K, Tavella, S, Thielemann, C, Willaert, R, Monici, M & Szewczyk, NJ 2024, 'How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?', npj Microgravity, vol. 10, no. 1, 50. https://doi.org/10.1038/s41526-024-00395-3