How proteins move lipids and lipids move proteins

H. Sprong; P. van der Sluijs; G. van Meer

doi:10.1038/35080071

How proteins move lipids and lipids move proteins

H. Sprong, P. van der Sluijs, G. van Meer

University Medical Center Utrecht

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Cells determine the bilayer characteristics of different membranes by tightly controlling their lipid composition. Local changes in the physical properties of bilayers, in turn, allow membrane deformation, and facilitate vesicle budding and fusion. Moreover, specific lipids at specific locations recruit cytosolic proteins involved in structural functions or signal transduction. We describe here how the distribution of lipids is directed by proteins, and, conversely, how lipids influence the distribution and function of proteins.

Original language	English
Pages (from-to)	504-513
Number of pages	10
Journal	Nature Reviews Molecular Cell Biology
Volume	2
DOIs	https://doi.org/10.1038/35080071
Publication status	Published - 2001

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title = "How proteins move lipids and lipids move proteins",

abstract = "Cells determine the bilayer characteristics of different membranes by tightly controlling their lipid composition. Local changes in the physical properties of bilayers, in turn, allow membrane deformation, and facilitate vesicle budding and fusion. Moreover, specific lipids at specific locations recruit cytosolic proteins involved in structural functions or signal transduction. We describe here how the distribution of lipids is directed by proteins, and, conversely, how lipids influence the distribution and function of proteins.",

author = "H. Sprong and {van der Sluijs}, P. and {van Meer}, G.",

note = "Erratum in: Nat Rev Mol Cell Biol 2001 Sep;2(9):698",

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AU - van der Sluijs, P.

AU - van Meer, G.

N1 - Erratum in: Nat Rev Mol Cell Biol 2001 Sep;2(9):698

PY - 2001

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AB - Cells determine the bilayer characteristics of different membranes by tightly controlling their lipid composition. Local changes in the physical properties of bilayers, in turn, allow membrane deformation, and facilitate vesicle budding and fusion. Moreover, specific lipids at specific locations recruit cytosolic proteins involved in structural functions or signal transduction. We describe here how the distribution of lipids is directed by proteins, and, conversely, how lipids influence the distribution and function of proteins.

U2 - 10.1038/35080071

DO - 10.1038/35080071

M3 - Article

SN - 1471-0072

VL - 2

SP - 504

EP - 513

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

ER -

How proteins move lipids and lipids move proteins

Abstract

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