Abstract
BACKGROUND: Anti-ganglioside antibodies with a pathogenic potential are present in C. jejuni-associated Guillain-Barré syndrome (GBS) patients and are probably induced by molecular mimicry. Immunization studies in rabbits and mice have demonstrated that these anti-ganglioside antibodies can be induced using purified lipo-oligosaccharides (LOS) from C. jejuni in a strong adjuvant.
METHODOLOGY/PRINCIPAL FINDINGS: To investigate whether natural colonization of chickens with a ganglioside-mimicking C. jejuni strain induces an anti-ganglioside response, and to investigate the diversity in anti-ganglioside response between and within genetically different chicken lines, we orally challenged chickens with different C. jejuni strains. Oral challenge of chickens with a C. jejuni strain from a GBS patient, containing a LOS that mimics ganglioside GM1, induced specific IgM and IgG anti-LOS and anti-GM1 antibodies. Inoculation of chickens with the Penner HS:3 serostrain, without a GM1-like structure, induced anti-LOS but no anti-ganglioside antibodies. We observed different patterns of anti-LOS/ganglioside response between and within the five strains of chickens.
CONCLUSIONS: Natural infection of chickens with C. jejuni induces anti-ganglioside antibodies. The production of antibodies is governed by both microbial and host factors.
Original language | English |
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Pages (from-to) | e9820 |
Number of pages | 1 |
Journal | PLoS One |
Volume | 5 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2010 |
Keywords
- Adjuvants, Immunologic
- Animals
- Campylobacter jejuni
- Chickens
- G(M1) Ganglioside
- Guillain-Barre Syndrome
- Immunization
- Immunoglobulin G
- Kinetics
- Lipopolysaccharides
- Mice
- Molecular Mimicry
- Rabbits
- Species Specificity