Hormonal Regulation of Stem Cell Proliferation at the Arabidopsis thaliana Root Stem Cell Niche

Mónica L. García-Gómez, Adriana Garay-Arroyo, Berenice García-Ponce, María de la Paz Sánchez, Elena R. Álvarez-Buylla*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The root stem cell niche (SCN) of Arabidopsis thaliana consists of the quiescent center (QC) cells and the surrounding initial stem cells that produce progeny to replenish all the tissues of the root. The QC cells divide rather slowly relative to the initials, yet most root tissues can be formed from these cells, depending on the requirements of the plant. Hormones are fundamental cues that link such needs with the cell proliferation and differentiation dynamics at the root SCN. Nonetheless, the crosstalk between hormone signaling and the mechanisms that regulate developmental adjustments is still not fully understood. Developmental transcriptional regulatory networks modulate hormone biosynthesis, metabolism, and signaling, and conversely, hormonal responses can affect the expression of transcription factors involved in the spatiotemporal patterning at the root SCN. Hence, a complex genetic–hormonal regulatory network underlies root patterning, growth, and plasticity in response to changing environmental conditions. In this review, we summarize the scientific literature regarding the role of hormones in the regulation of QC cell proliferation and discuss how hormonal signaling pathways may be integrated with the gene regulatory network that underlies cell fate in the root SCN. The conceptual framework we present aims to contribute to the understanding of the mechanisms by which hormonal pathways act as integrators of environmental cues to impact on SCN activity.

Original languageEnglish
Article number628491
Pages (from-to)1-14
JournalFrontiers in Plant Science
Volume12
DOIs
Publication statusPublished - 3 Mar 2021
Externally publishedYes

Bibliographical note

Funding Information:
This study was financed with the following grants: Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica Universidad Nacional Autónoma de México (UNAM-DGAPA-PAPIIT http://dgapa.unam.mx/index.php/impulso-a-la-investigacion/papiit): IN200920, IN203220, IN206220, IN211721, and Consejo Nacional de Ciencia y Tecnología (CONACyT): 102959 and 102987. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Funding Information:
We acknowledge the help from Diana Bel?n S?nchez-Rodr?guez with various logistical tasks. Funding. This study was financed with the following grants: Programa de Apoyo a Proyectos de Investigaci?n e Innovaci?n Tecnol?gica Universidad Nacional Aut?noma de M?xico (UNAM-DGAPA-PAPIIT http://dgapa.unam.mx/index.php/impulso-a-la-investigacion/papiit): IN200920, IN203220, IN206220, IN211721, and Consejo Nacional de Ciencia y Tecnolog?a (CONACyT): 102959 and 102987. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© Copyright © 2021 García-Gómez, Garay-Arroyo, García-Ponce, Sánchez and Álvarez-Buylla.

Funding

This study was financed with the following grants: Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica Universidad Nacional Autónoma de México (UNAM-DGAPA-PAPIIT http://dgapa.unam.mx/index.php/impulso-a-la-investigacion/papiit): IN200920, IN203220, IN206220, IN211721, and Consejo Nacional de Ciencia y Tecnología (CONACyT): 102959 and 102987. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We acknowledge the help from Diana Bel?n S?nchez-Rodr?guez with various logistical tasks. Funding. This study was financed with the following grants: Programa de Apoyo a Proyectos de Investigaci?n e Innovaci?n Tecnol?gica Universidad Nacional Aut?noma de M?xico (UNAM-DGAPA-PAPIIT http://dgapa.unam.mx/index.php/impulso-a-la-investigacion/papiit): IN200920, IN203220, IN206220, IN211721, and Consejo Nacional de Ciencia y Tecnolog?a (CONACyT): 102959 and 102987. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Keywords

  • gene regulatory networks
  • hormonal regulation
  • plant development
  • quiescent center
  • root stem cell niche
  • stem cell regulation

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