Hold the fold: how delayed folding aids protein secretion

Nicholas McCaul; Ineke Braakman

doi:10.15252/embj.2022112787

Hold the fold: how delayed folding aids protein secretion

Nicholas McCaul^*
, Ineke Braakman^*

^*Corresponding author for this work

University of Huddersfield

Research output: Contribution to journal › Article › Academic

Abstract

In bacteria, N-terminal signal peptides mark proteins for transport across the plasma membrane. A recent study by Smets et al (2022) followed the folding of a pair of structural twins to shed light on how evolution has optimised the secretory process.

Original language	English
Article number	e112787
Number of pages	3
Journal	EMBO Journal
Volume	41
Issue number	23
DOIs	https://doi.org/10.15252/embj.2022112787
Publication status	Published - 1 Dec 2022

Bibliographical note

Keywords

Protein Transport
Protein Sorting Signals
Proteins
Cell Membrane
Protein Folding

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.15252/embj.2022112787

mccaul-braakman-2022-hold-the-fold-how-delayed-folding-aids-protein-secretionFinal published version, 407 KBLicence: Taverne

Cite this

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title = "Hold the fold: how delayed folding aids protein secretion",

abstract = "In bacteria, N-terminal signal peptides mark proteins for transport across the plasma membrane. A recent study by Smets et al (2022) followed the folding of a pair of structural twins to shed light on how evolution has optimised the secretory process.",

keywords = "Protein Transport, Protein Sorting Signals, Proteins, Cell Membrane, Protein Folding",

author = "Nicholas McCaul and Ineke Braakman",

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AU - Braakman, Ineke

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AB - In bacteria, N-terminal signal peptides mark proteins for transport across the plasma membrane. A recent study by Smets et al (2022) followed the folding of a pair of structural twins to shed light on how evolution has optimised the secretory process.

KW - Protein Transport

KW - Protein Sorting Signals

KW - Proteins

KW - Cell Membrane

KW - Protein Folding

UR - https://www.scopus.com/pages/publications/85141144686

U2 - 10.15252/embj.2022112787

DO - 10.15252/embj.2022112787

M3 - Article

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SN - 0261-4189

VL - 41

JO - EMBO Journal

JF - EMBO Journal

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ER -

Hold the fold: how delayed folding aids protein secretion

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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