Hepatitis B after infection of a chimpanzee with cloned HBV DNA.

H. Will; G. Darai; F. Deinhardt; H. Schellekens; H. Schaller

Hepatitis B after infection of a chimpanzee with cloned HBV DNA.

H. Will^*, G. Darai, F. Deinhardt, H. Schellekens, H. Schaller

^*Corresponding author for this work

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Transfection of chimpanzee liver cells in vivo or in vitro with cloned HBV DNA induced typical hepatitis B in the inoculated animal. Intravenous inoculation of a 1000-fold greater dose of the same cloned HBV DNA did not induce infection or disease. The experiment proved that cloned HBV DNA is fully functional and that the nick gap structure, proteins covalently linked to the HBV genome, or any other HBV particle associated protein are not needed for initiation of virus replication.

Original language	English
Pages (from-to)	131-133
Number of pages	3
Journal	Developments in Biological Standardization
Volume	54
Publication status	Published - 1 Dec 1983
Externally published	Yes

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title = "Hepatitis B after infection of a chimpanzee with cloned HBV DNA.",

abstract = "Transfection of chimpanzee liver cells in vivo or in vitro with cloned HBV DNA induced typical hepatitis B in the inoculated animal. Intravenous inoculation of a 1000-fold greater dose of the same cloned HBV DNA did not induce infection or disease. The experiment proved that cloned HBV DNA is fully functional and that the nick gap structure, proteins covalently linked to the HBV genome, or any other HBV particle associated protein are not needed for initiation of virus replication.",

author = "H. Will and G. Darai and F. Deinhardt and H. Schellekens and H. Schaller",

year = "1983",

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day = "1",

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T1 - Hepatitis B after infection of a chimpanzee with cloned HBV DNA.

AU - Will, H.

AU - Darai, G.

AU - Deinhardt, F.

AU - Schellekens, H.

AU - Schaller, H.

PY - 1983/12/1

Y1 - 1983/12/1

N2 - Transfection of chimpanzee liver cells in vivo or in vitro with cloned HBV DNA induced typical hepatitis B in the inoculated animal. Intravenous inoculation of a 1000-fold greater dose of the same cloned HBV DNA did not induce infection or disease. The experiment proved that cloned HBV DNA is fully functional and that the nick gap structure, proteins covalently linked to the HBV genome, or any other HBV particle associated protein are not needed for initiation of virus replication.

AB - Transfection of chimpanzee liver cells in vivo or in vitro with cloned HBV DNA induced typical hepatitis B in the inoculated animal. Intravenous inoculation of a 1000-fold greater dose of the same cloned HBV DNA did not induce infection or disease. The experiment proved that cloned HBV DNA is fully functional and that the nick gap structure, proteins covalently linked to the HBV genome, or any other HBV particle associated protein are not needed for initiation of virus replication.

UR - https://www.scopus.com/pages/publications/0020985107

M3 - Article

C2 - 6653885

AN - SCOPUS:0020985107

SN - 0301-5149

VL - 54

SP - 131

EP - 133

JO - Developments in Biological Standardization

JF - Developments in Biological Standardization

ER -

Hepatitis B after infection of a chimpanzee with cloned HBV DNA.

Abstract

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